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Xiaoyan Qian
Researcher at Science for Life Laboratory
Publications - 34
Citations - 1966
Xiaoyan Qian is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 13, co-authored 26 publications receiving 942 citations. Previous affiliations of Xiaoyan Qian include Peking Union Medical College & Fudan University.
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Journal ArticleDOI
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
Journal ArticleDOI
A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart
Michaela Asp,Stefania Giacomello,Ludvig Larsson,Chenglin Wu,Daniel Fürth,Xiaoyan Qian,Eva Wärdell,Joaquin Custodio,Johan Reimegård,Fredrik Salmén,Cecilia Österholm,Patrik L. Ståhl,Erik Sundström,Elisabet Åkesson,Olaf Bergmann,Magda Bienko,Agneta Månsson-Broberg,Mats Nilsson,Christer Sylvén,Joakim Lundeberg +19 more
TL;DR: A molecular approach is presented that reveals the comprehensive transcriptional landscape of cell types populating the embryonic heart at three developmental stages and that maps cell-type-specific gene expression to specific anatomical domains.
Journal ArticleDOI
Spatiotemporal structure of cell fate decisions in murine neural crest
Ruslan A. Soldatov,Marketa Kaucka,Marketa Kaucka,Maria Eleni Kastriti,Maria Eleni Kastriti,Julian Petersen,Julian Petersen,Tatiana Chontorotzea,Lukas Englmaier,Natalia Akkuratova,Natalia Akkuratova,Yunshi Yang,Martin Häring,Viacheslav Dyachuk,Viacheslav Dyachuk,Christoph Bock,Christoph Bock,Christoph Bock,Matthias Farlik,Michael L. Piacentino,Franck Boismoreau,Markus M. Hilscher,Markus M. Hilscher,Chika Yokota,Xiaoyan Qian,Mats Nilsson,Marianne E. Bronner,Laura Croci,Wen Yu Hsiao,David A. Guertin,Jean-François Brunet,G. Giacomo Consalez,Patrik Ernfors,Kaj Fried,Peter V. Kharchenko,Igor Adameyko,Igor Adameyko +36 more
TL;DR: It is found that up to early migration, neural crest cells progress through a sequence of common transcriptional states, followed by fate bifurcations during migration that can be formalized as a series of sequential binary decisions.
Journal ArticleDOI
Probabilistic cell typing enables fine mapping of closely related cell types in situ.
Xiaoyan Qian,Kenneth D. Harris,Thomas Hauling,Thomas Hauling,Dimitris Nicoloutsopoulos,Ana B. Muñoz-Manchado,Nathan G. Skene,Nathan G. Skene,Jens Hjerling-Leffler,Mats Nilsson +9 more
TL;DR: This work introduces probabilistic cell typing by in situ sequencing (pciSeq), an approach that leverages previous scRNA-seq classification to identify cell types using multiplexed in situ RNA detection to spatially map cell types accurately in the mouse hippocampus and isocortex.
Journal ArticleDOI
Profiling surface proteins on individual exosomes using a proximity barcoding assay.
Di Wu,Junhong Yan,Xia Shen,Xia Shen,Xia Shen,Yu Sun,Yu Sun,Måns Thulin,Måns Thulin,Yanling Cai,Lotta Wik,Qiujin Shen,Johan Oelrich,Xiaoyan Qian,K Louise Dubois,K. Göran Ronquist,Mats Nilsson,Ulf Landegren,Masood Kamali-Moghaddam +18 more
TL;DR: A proximity-dependent barcoding assay is demonstrated to be able to profile surface proteins of individual exosomes using antibody-DNA conjugates and next-generation sequencing and it is demonstrated that 38 surface proteins from heterogeneous samples such as serum and seminal fluid are profileable.