Alesia Antoine

TL;DR: Preliminary analysis of clinical trial data suggests that breast cancers with double mutations are more responsive to PI3K inhibitors than those with a single mutation, and PIK3CA mutational status could help identify the breast cancer patients most likely to benefit from these drugs.

TL;DR: It is established that human induced pluripotent stem cell (hiPSC)-derived neurons well represent the diversity of NRXN1α alternative splicing observed in the human brain, cataloguing 123 high-confidence in-frame human NRXn1α isoforms.

TL;DR: The combination of SMRT sequencing with the IMGT/HighV-QUEST querying tool will facilitate and expedite the understanding of polyclonal antibody responses during SIV infection and may serve to rapidly expand the known scope of macaque V genes utilized during these responses.

TL;DR: This work demonstrates the multifaceted capabilities of a novel nanofluidic platform to enable single-cell phenotypic and genetic profiling of ovarian cancer patient-derived tumor cells, providing a better understanding of underlying biological drivers of the disease.

TL;DR: A comprehensive analysis of the prevalence of multiple PIK3CA mutations and their potential biological relevance and correlation with sensitivity to PI3Kα inhibitors shows that cis mutants have increased kinase activity compared to single mutants and that this activation is due to both increased p85α disruption and increased lipid binding, compared tosingle mutants.