Y
Ying-Chih Wang
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 34
Citations - 3037
Ying-Chih Wang is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 13, co-authored 30 publications receiving 1842 citations.
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Journal ArticleDOI
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Lu Xie,Ben Readhead,Eli A. Stahl,Jianqiu Xiao,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,Towfique Raj,David A. Bennett,Philip L. De Jager,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutunian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +60 more
TL;DR: It is shown that schizophrenia is polygenic and the utility of this resource of gene expression and its genetic regulation for mechanistic interpretations of genetic liability for brain diseases is highlighted.
Journal ArticleDOI
Negative feedback control of neuronal activity by microglia
Ana Badimon,Hayley J. Strasburger,Pinar Ayata,Xinhong Chen,Aditya Nair,Ako Ikegami,Ako Ikegami,Philip Hwang,Andrew T. Chan,Steven M. Graves,Joseph O. Uweru,Carola Ledderose,Munir Gunes Kutlu,Michael A. Wheeler,Anat Kahan,Masago Ishikawa,Ying-Chih Wang,Yong-Hwee E. Loh,Jean X. Jiang,D. James Surmeier,Simon C. Robson,Wolfgang G. Junger,Robert Sebra,Erin S. Calipari,Paul J. Kenny,Ukpong B. Eyo,Marco Colonna,Francisco J. Quintana,Francisco J. Quintana,Hiroaki Wake,Hiroaki Wake,Viviana Gradinaru,Anne Schaefer +32 more
TL;DR: It is suggested that this microglia-driven negative feedback mechanism operates similarly to inhibitory neurons and is essential for protecting the brain from excessive activation in health and disease.
Journal ArticleDOI
Introductions and early spread of SARS-CoV-2 in the New York City area.
Ana S. Gonzalez-Reiche,Matthew M. Hernandez,Mitchell J. Sullivan,Brianne Ciferri,Hala Alshammary,Ajay Obla,Shelcie Fabre,Giulio Kleiner,Jose Polanco,Zenab Khan,Bremy Alburquerque,Adriana van de Guchte,Jayeeta Dutta,Nancy Francoeur,Betsaida Salom Melo,Irina Oussenko,Gintaras Deikus,Juan C. Diaz Soto,Shwetha Hara Sridhar,Ying-Chih Wang,Kathryn Twyman,Andrew Kasarskis,Andrew Kasarskis,Deena R. Altman,Melissa Smith,Robert Sebra,Judith A. Aberg,Florian Krammer,Adolfo García-Sastre,Marta Luksza,Gopi Patel,Alberto Paniz-Mondolfi,Melissa R. Gitman,Emilia Mia Sordillo,Viviana Simon,Viviana Simon,Harm van Bakel +36 more
TL;DR: To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, the virus that causes coronavirus disease 2019 (COVID-19) was sequenced in patients seeking care at the Mount Sinai Health System.
Journal ArticleDOI
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility
Towfique Raj,Yang I. Li,Garrett Wong,Jack Humphrey,Minghui Wang,Satesh Ramdhani,Ying-Chih Wang,Bryan C. Ng,Ishaan Gupta,Vahram Haroutunian,Vahram Haroutunian,Eric E. Schadt,Tracy L. Young-Pearse,Sara Mostafavi,Bin Zhang,Pamela Sklar,David A. Bennett,Philip L. De Jager,Philip L. De Jager +18 more
TL;DR: This study of the transcriptome of the aging brain provides evidence that dysregulation of mRNA splicing is a feature of Alzheimer’s disease and is, in some cases, genetically driven.
Posted ContentDOI
Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia
Menachem Fromer,Panos Roussos,Solveig K. Sieberts,Jessica S. Johnson,David H. Kavanagh,Thanneer M. Perumal,Douglas M. Ruderfer,Edwin C. Oh,Aaron Topol,Hardik Shah,Lambertus Klei,Robin Kramer,Dalila Pinto,Zeynep H. Gümüş,A. Ercument Cicek,Kristen K. Dang,Andrew W. Browne,Cong Lu,Li Xie,Ben Readhead,Eli A. Stahl,Mahsa Parvisi,Tymor Hamamsy,John F. Fullard,Ying-Chih Wang,Milind Mahajan,Jonathan M. J. Derry,Joel T. Dudley,Scott E. Hemby,Benjamin A. Logsdon,Konrad Talbot,Towfique Raj,David A. Bennett,Philip L. De Jager,Jun Zhu,Bin Zhang,Patrick F. Sullivan,Andrew Chess,Shaun Purcell,Leslie A. Shinobu,Lara M. Mangravite,Hiroyoshi Toyoshiba,Raquel E. Gur,Chang-Gyu Hahn,David A. Lewis,Vahram Haroutonian,Mette A. Peters,Barbara K. Lipska,Joseph D. Buxbaum,Eric E. Schadt,Keisuke Hirai,Kathryn Roeder,Kristen J. Brennand,Nicholas Katsanis,Enrico Domenici,Bernie Devlin,Pamela Sklar +56 more
TL;DR: Co-expression analyses identify a gene module that shows enrichment for genetic associations and is thus relevant for schizophrenia, paving the way for mechanistic interpretations of genetic liability for schizophrenia and other brain diseases.