Alessandra Amendola

TL;DR: Contact with HIV-1 envelope protein elicits release of ATP through pannexin-1 channels on target cells; by activating purinergic receptors and Pyk2 kinase in target cells, this extracellular ATP boosts HIV- 1 infectivity.

TL;DR: The capacity of MTB to induce apoptosis in cells obtained by broncho‐alveolar lavage from patients with reactive pulmonary tuberculosis and from AIDS patients with disseminated pulmonary tuberculosis is analyzed.

TL;DR: It is demonstrated that phosphorylation of p53S15 by mTOR/FRAP plays a critical role in syncytial apoptosis driven by HIV-1 Env, as well as in peripheral blood mononuclear cells, correlating with viral load.

TL;DR: HIV‐1 elicits a pro‐apoptotic signal transduction pathway relying on the sequential action of cyclin B–Cdk1, mTOR and p53, which prevents karyogamy, m TOR activation, p53S15 phosphorylation and apoptosis.

TL;DR: The pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment in patients identified in Italy with COVID-19 infection travelling from Wuhan, China.