Alessandra Pincini

TL;DR: The invasive signatures associated with concomitant p130Cas overexpression and ErbB2 activation in 3D cultures of mammary epithelial cells are defined and the expression of specific miRNAs is altered.

TL;DR: This work discusses the molecular features of p130Cas and p140Cap proteins in terms of regulation of cell migration and invasion in normal and transformed cells.

TL;DR: High levels of p130Cas, via abnormal c‐Kit activation, promote mammary luminal cell plasticity, thus providing the conditions for the development of basal‐like breast cancer.

TL;DR: It is demonstrated that p130Cas over-expression upon the concomitant stimulation with EGF and estrogen (E2) severely impairs mammary morphogenesis giving rise to enlarged multicellular spherical structures with altered architecture and absence of the central lumen, suggesting that alteration of morphogenetic pathways due to p130 Cas over- expression might prime mammary epithelium to tumorigenesis.

TL;DR: This chapter discusses recent data on the relevance of p130Cas and p140Cap adaptor molecules in breast cancer signalling related to the acquirement on invasive properties and the increasing evidence that highlight the importance of these adaptor proteins in Breast cancer.