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Alex Zwanenburg
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 45
Citations - 3234
Alex Zwanenburg is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Medicine & Feature (computer vision). The author has an hindex of 18, co-authored 36 publications receiving 1769 citations. Previous affiliations of Alex Zwanenburg include German Cancer Research Center & Maastricht University.
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Journal ArticleDOI
The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-based Phenotyping
Alex Zwanenburg,Alex Zwanenburg,Martin Vallières,Mahmoud A. Abdalah,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Vincent Andrearczyk,Aditya Apte,Saeed Ashrafinia,Spyridon Bakas,Roelof J. Beukinga,Ronald Boellaard,Marta Bogowicz,Luca Boldrini,Irène Buvat,Gary Cook,Christos Davatzikos,Adrien Depeursinge,Marie-Charlotte Desseroit,Nicola Dinapoli,Cuong V. Dinh,Sebastian Echegaray,Issam El Naqa,Issam El Naqa,Andriy Fedorov,Roberto Gatta,Robert J. Gillies,Vicky Goh,Michael Götz,Matthias Guckenberger,Sung Min Ha,Mathieu Hatt,Fabian Isensee,Philippe Lambin,Stefan Leger,Stefan Leger,Ralph T.H. Leijenaar,Jacopo Lenkowicz,Fiona Lippert,Are Losnegård,Klaus H. Maier-Hein,Olivier Morin,Henning Müller,Sandy Napel,Christophe Nioche,Fanny Orlhac,Sarthak Pati,Elisabeth Pfaehler,Arman Rahmim,Arman Rahmim,Arvind Rao,Jonas Scherer,Muhammad Siddique,Nanna M. Sijtsema,Jairo Socarras Fernandez,Emiliano Spezi,Roel J H M Steenbakkers,Stephanie Tanadini-Lang,Daniela Thorwarth,Esther G.C. Troost,Esther G.C. Troost,Taman Upadhaya,Vincenzo Valentini,Lisanne V. van Dijk,Joost J. M. van Griethuysen,Floris H. P. van Velden,Philip Whybra,Christian Richter,Christian Richter,Steffen Löck,Steffen Löck +70 more
TL;DR: A set of 169 radiomics features was standardized, which enabled verification and calibration of different radiomics software and could be excellently reproduced.
Journal ArticleDOI
Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia
Daan R. M. G. Ophelders,Tim G. A. M. Wolfs,Reint K. Jellema,Alex Zwanenburg,Peter Andriessen,Tammo Delhaas,Anna Kristin Ludwig,Stefan Radtke,Stefan Radtke,Vera Maria Peters,Leon E. W. Janssen,Bernd Giebel,Boris W. Kramer +12 more
TL;DR: The study results suggest that a cell‐free preparation comprising neuroprotective MSC‐EVs could substitute MSCs in the treatment of preterm neonates with hypoxic‐ischemic brain injury, thereby circumventing the potential risks of systemic administration of living cells.
Journal ArticleDOI
Radiomics in nuclear medicine: robustness, reproducibility, standardization, and how to avoid data analysis traps and replication crisis.
TL;DR: A meta-analysis to investigate reproducibility of radiomics biomarkers in PET imaging and to obtain quantitative information regarding their sensitivity to variations in various imaging and radiomics-related factors as well as their inherent sensitivity is performed.
Journal ArticleDOI
A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling.
Stefan Leger,Stefan Leger,Alex Zwanenburg,K. Pilz,Fabian Lohaus,Annett Linge,Klaus Zöphel,Klaus Zöphel,Jörg Kotzerke,Jörg Kotzerke,Andreas Schreiber,Inge Tinhofer,Inge Tinhofer,Volker Budach,Volker Budach,Ali Sak,Ali Sak,Martin Stuschke,Martin Stuschke,Panagiotis Balermpas,Panagiotis Balermpas,Claus Rödel,Claus Rödel,Ute Ganswindt,Ute Ganswindt,Claus Belka,Steffi Pigorsch,Steffi Pigorsch,Stephanie E. Combs,Stephanie E. Combs,David Mönnich,David Mönnich,Daniel Zips,Daniel Zips,Mechthild Krause,Michael Baumann,Esther G.C. Troost,Steffen Löck,Steffen Löck,Steffen Löck,Christian Richter +40 more
TL;DR: A subset of algorithms are identified which should be considered in future radiomics studies to develop stable and clinically relevant predictive models for time-to-event endpoints.
Journal ArticleDOI
Responsible Radiomics Research for Faster Clinical Translation.
Martin Vallières,Alex Zwanenburg,Bodgan Badic,Catherine Cheze Le Rest,Dimitris Visvikis,Mathieu Hatt +5 more
TL;DR: The aim of this editorial is to present guidelines that can improve the reporting quality and therefore the reproducibility of radiomics studies, as well as the statistical quality of radiochemistry analyses, and to describe how imaging features can reflect gene expression.