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Alexander Arefolov
Researcher at Boston University
Publications - 9
Citations - 638
Alexander Arefolov is an academic researcher from Boston University. The author has contributed to research in topics: Discodermolide & Enantioselective synthesis. The author has an hindex of 8, co-authored 9 publications receiving 562 citations. Previous affiliations of Alexander Arefolov include Harvard University.
Papers
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Journal ArticleDOI
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Henry E. Pelish,Brian B. Liau,Ioana Nitulescu,Anupong Tangpeerachaikul,Zachary C. Poss,Diogo H. Da Silva,Brittany T. Caruso,Alexander Arefolov,Olugbeminiyi O Fadeyi,Amanda L. Christie,Karrie Du,Deepti Banka,E.V. Schneider,Anja Jestel,Ge Zou,Chong Si,Christopher C. Ebmeier,Roderick T. Bronson,Andrei V. Krivtsov,Andrew G. Myers,Nancy E. Kohl,Andrew L. Kung,Scott A. Armstrong,Madeleine E. Lemieux,Dylan J. Taatjes,Matthew D. Shair +25 more
TL;DR: It is shown that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.
Patent
Methods for treating hepatitis c
Gary Mitchell Karp,Peter Seongwoo Hwang,James J. Takasugi,Hongyu Ren,Richard G. Wilde,Anthony Turpoff,Alexander Arefolov,Guangming Chen,Jeffrey Allen Campbell +8 more
TL;DR: In this article, the authors present compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity, and they provide a list of such compounds and compositions.
Journal ArticleDOI
Crotylsilane Reagents in the Synthesis of Complex Polyketide Natural Products: Total Synthesis of (+)-Discodermolide
TL;DR: An efficient, highly convergent stereocontrolled synthesis of (+)-discodermolide has been achieved with 2.1% overall yield (27 steps longest linear sequence) using asymmetric crotylation methodology.
Journal ArticleDOI
Stereoselective synthesis of functionalized trisubstituted olefins via palladium(0)-catalyzed cross-coupling reaction.
TL;DR: A highly flexible and stereoselective protocol for the synthesis of branched (E)- and (Z)-trisubstituted alkenes has been developed and the key steps are hydrozirconation-iodination of (1-alkynyl)trimethylsilane followed by Negishi-type cross-coupling.
Journal ArticleDOI
Studies directed toward the total synthesis of discodermolide: asymmetric synthesis of the C1-C14 fragment.
TL;DR: A convergent and stereoselective assembly of the C1-C14 subunit of marine natural product (+)-discodermolide has been completed and the approach employs chiral allylsilane bond construction methodology to establish four of the eight stereogenic centers.