Zachary C. Poss

TL;DR: The basics that underlie Mediator function are focused on, such as its structure and subunit composition, and its broad regulatory influence on gene expression, ranging from chromatin architecture to transcription initiation and elongation, to mRNA processing.

TL;DR: It is shown that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.

TL;DR: It is shown that the cyclin-dependent kinase 8 (CDK8) module of the Mediator complex phosphorylated regulatory sites within the TADs of STAT1, STAT3, and STAT5, including S727 within the STAT1 TAD in the interferon (IFN) signaling pathway, suggesting a general role for CDK8 in STAT-mediated transcription.

TL;DR: Quantitative proteome analyses revealed that CA selectively affected pathways implicated in inflammation, growth, and metabolic regulation, and increased turnover of Mediator kinase targets was not generally observed.

TL;DR: It is established that CDK7 directly activates other transcription-associated kinases CDK9, CDK12, and CDK13, invoking a "master regulator" role in transcription and implicate CAK dissociation from TFIIH as essential for kinase activation.