D
Deepti Banka
Researcher at Boston Children's Hospital
Publications - 9
Citations - 821
Deepti Banka is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: DOT1L & Leukemia. The author has an hindex of 6, co-authored 7 publications receiving 706 citations. Previous affiliations of Deepti Banka include Harvard University & Columbia University.
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Journal ArticleDOI
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Henry E. Pelish,Brian B. Liau,Ioana Nitulescu,Anupong Tangpeerachaikul,Zachary C. Poss,Diogo H. Da Silva,Brittany T. Caruso,Alexander Arefolov,Olugbeminiyi O Fadeyi,Amanda L. Christie,Karrie Du,Deepti Banka,E.V. Schneider,Anja Jestel,Ge Zou,Chong Si,Christopher C. Ebmeier,Roderick T. Bronson,Andrei V. Krivtsov,Andrew G. Myers,Nancy E. Kohl,Andrew L. Kung,Scott A. Armstrong,Madeleine E. Lemieux,Dylan J. Taatjes,Matthew D. Shair +25 more
TL;DR: It is shown that the Mediator-associated kinases cyclin-dependent kinase 8 (CDK8) and CDK19 restrain increased activation of key SE-associated genes in acute myeloid leukaemia (AML) cells.
Journal ArticleDOI
Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l
Aniruddha J. Deshpande,Aniruddha J. Deshpande,Aniruddha J. Deshpande,Liying Chen,Liying Chen,Maurizio Fazio,Amit U. Sinha,Amit U. Sinha,Amit U. Sinha,Kathrin M. Bernt,Kathrin M. Bernt,Kathrin M. Bernt,Deepti Banka,Deepti Banka,Stuart Dias,Stuart Dias,Jenny Chang,Jenny Chang,Jenny Chang,Edward J. Olhava,Scott R. Daigle,Victoria M. Richon,Roy M. Pollock,Scott A. Armstrong +23 more
TL;DR: It is demonstrated that MLL-AF6 requires continued activity of the histone-methyltransferase DOT1L to maintain expression of the MLLAF6-driven oncogenic gene-expression program, and patients bearing the t(6;11)(q27;q23) translocation may benefit from therapeutic agents targeting aberrant H3K79 methylation.
Journal ArticleDOI
AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes
Aniruddha J. Deshpande,Anagha Deshpande,Amit U. Sinha,Liying Chen,Jenny Chang,Ali Cihan,Maurizio Fazio,Chun-Wei Chen,Nan Zhu,Richard Koche,Liuda Dzhekieva,Gloria Ibáñez,Stuart Dias,Deepti Banka,Andrei V. Krivtsov,Minkui Luo,Robert G. Roeder,James E. Bradner,Kathrin M. Bernt,Scott A. Armstrong,Scott A. Armstrong +20 more
TL;DR: It is demonstrated that pharmacological inhibition of the DOT1L/AF10 complex may provide therapeutic benefits in an array of malignancies with abnormal HOXA gene expression.
Journal ArticleDOI
Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
Liying Chen,Aniruddha J. Deshpande,Deepti Banka,Kathrin M. Bernt,Stuart Dias,Christian Buske,Edward J. Olhava,Scott R. Daigle,Victoria M. Richon,Roy M. Pollock,Scott A. Armstrong +10 more
TL;DR: Results show that patients with leukemia-bearing chromosomal translocations that involve the AF10 gene may benefit from small-molecule therapeutics that inhibit H3K79 methylation.
Journal ArticleDOI
Peroxisome biogenesis disorders: the role of peroxisomes and metabolic dysfunction in developing brain.
TL;DR: The use of several in vitro cell culture assays to evaluate the migration and differentiation of cerebellar neurons demonstrates a persistence of defects in peroxisome-deficient neurons, which indicates that CNS intrinsic defects contribute to the pathogenesis of disease in these disorders.