A
Alexander E. Gorbalenya
Researcher at Moscow State University
Publications - 202
Citations - 35905
Alexander E. Gorbalenya is an academic researcher from Moscow State University. The author has contributed to research in topics: RNA & RNA-dependent RNA polymerase. The author has an hindex of 85, co-authored 198 publications receiving 30931 citations. Previous affiliations of Alexander E. Gorbalenya include Business International Corporation & Academy of Medical Sciences, United Kingdom.
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Mutational analysis of the active centre of coronavirus 3C-like proteases
TL;DR: It is concluded that both the catalytic systems and substrate-binding pockets of coronavirus main proteases differ from those of other RNA virus 3C and 3C-like proteases.
Journal ArticleDOI
Arterivirus Subgenomic mRNA Synthesis and Virion Biogenesis Depend on the Multifunctional nsp1 Autoprotease
Marieke A. Tijms,Danny D. Nedialkova,Jessika C. Zevenhoven-Dobbe,Alexander E. Gorbalenya,Eric J. Snijder +4 more
TL;DR: The role of nsp1 in the EAV life cycle has been investigated using reverse genetics in this article, which revealed that Nsp1 is a multifunctional regulatory protein, responsible for replicase polyprotein processing, transcription, and virion biogenesis.
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Arterivirus Nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs.
TL;DR: This first report on protein-mediated, mRNA-specific control of nidovirus RNA synthesis reveals the existence of an integral control mechanism to fine-tune replication, sg mRNA synthesis, and virus production, and establishes a major role for nsp1 in coordinating the arterivirus replicative cycle.
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50 years of the International Committee on Taxonomy of Viruses : progress and prospects
Michael J. Adams,Elliot J. Lefkowitz,Andrew M. Q. King,Balázs Harrach,Robert L. Harrison,Nick J. Knowles,Andrew M. Kropinski,Mart Krupovic,Jens H. Kuhn,Arcady Mushegian,Max L. Nibert,Sead Sabanadzovic,Hélène Sanfaçon,Stuart G. Siddell,Peter Simmonds,Arvind Varsani,Francisco Murilo Zerbini,Richard J. Orton,B. Douglas Smith,Alexander E. Gorbalenya,Alexander E. Gorbalenya,Andrew J. Davison +21 more
TL;DR: A brief history of the ICTV is presented, showing how it has adapted to advancements in knowledge of virus diversity and the methods used to characterize it, and recent developments that are facilitating substantial changes in the operations and promoting dialogue with the virology community are outlined.
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Recommendations for the nomenclature of enteroviruses and rhinoviruses
Peter Simmonds,Alexander E. Gorbalenya,Heli Harvala,Tapani Hovi,Nick J. Knowles,A. M. Lindberg,M. S. Oberste,Ann C. Palmenberg,Gábor Reuter,Tim Skern,Caroline Tapparel,Katja C. Wolthers,Patrick C. Y. Woo,Roland Zell +13 more
TL;DR: The correct use of taxon names for these viruses are described and a series of recommendations for the nomenclature of EV and RV types and their abbreviations are produced, believing their adoption will promote greater clarity and consistency in the terminology used in the scientific and medical literature.