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Alexander J. Lazar
Researcher at University of Texas MD Anderson Cancer Center
Publications - 578
Citations - 55895
Alexander J. Lazar is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Sarcoma & Medicine. The author has an hindex of 93, co-authored 487 publications receiving 38717 citations. Previous affiliations of Alexander J. Lazar include Baylor College of Medicine & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
Diagnosis, management, and outcome of patients with dedifferentiated liposarcoma systemic metastasis.
Markus P. Ghadimi,Tariq Al-Zaid,John E. Madewell,Tingsheng Peng,Chiara Colombo,Aviad Hoffman,Chad J. Creighton,Yiqun Zhang,Anna Zhang,Alexander J. Lazar,Raphael E. Pollock,Dina Lev +11 more
TL;DR: Metastatic spread is an ominous consequence of DDLPS, especially regarding de novo tumors, and further studies to identify metastatic biomarkers are needed.
Journal ArticleDOI
Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics
TL;DR: This poster presents a probabilistic procedure called a “ ‘cell reprograming’” (‘coding’) for the determination of the T-cell status of the placenta during pregnancy and the immune defences of the immune system are studied.
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Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors
Hui Shang,Hui Shang,Danielle Braggio,Danielle Braggio,Ya Jung Lee,Ghadah A. Al Sannaa,Chad J. Creighton,Svetlana Bolshakov,Alexander J. Lazar,Dina Lev,Raphael E. Pollock,Raphael E. Pollock +11 more
TL;DR: Treatment with PF‐03084014, a potent γ‐secretase inhibitor, has been shown to have antitumor activity in several tumor types by affecting the WNT/β‐catenin pathway, and might be a promising approach for DT treatment.
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Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions
Sean P. Dineen,Christina L. Roland,Rachel Feig,Caitlin D. May,Shouhao Zhou,Elizabeth G. Demicco,Ghadah A. Al Sannaa,Davis R. Ingram,Wei Lein Wang,Vinod Ravi,Ashleigh Guadagnolo,Dina Lev,Raphael E. Pollock,Kelly K. Hunt,Janice N. Cormier,Alexander J. Lazar,Barry W. Feig,Keila E. Torres +17 more
TL;DR: Local recurrence was significantly higher for patients with RA-UPS/MFH, suggesting a unique tumor biology for this challenging disease.
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Desmoid tumor: from surgical extirpation to molecular dissection.
TL;DR: Assessment and treatment of individual patients in a multidisciplinary setting is critical to achieve the most favorable outcome in this disease and additional study of the molecular determinates of desmoid behavior is needed to guide therapeutic selection.