Alexander J. Lazar

TL;DR: Copy number observations in human tumors and genetic experiments in mice render, for the first time, a functional landscape of the CCS genome, which advances efforts to understand the biology of CCS with innovative models.

TL;DR: ER and AR are commonly expressed in LS, particularly in well-differentiated tumors, and receptor status was not significantly associated with gender or race, but AR and PR expression were associated with earlier age at diagnosis.

TL;DR: This study compares the performance of assay methods, using either commercial kits or assays designed and implemented by single laboratories ("home brews") on proficiency testing provided by the College of American Pathologists Molecular Oncology Committee to demonstrate the high degree of accuracy and comparable performance across all laboratories, regardless of methodology.

TL;DR: In the 5th edition of the WHO classification of the Head and Neck Tumours establishing a new section dedicated to familial/heritable tumor syndromes with tumors and lesions in the head and neck region was much needed to better understand the tumours, diseases and associated syndrome, as well as establish recommendations for monitoring and treating these patients as mentioned in this paper .

TL;DR: The combination of durvalumab (D), (anti- PD-L1) and tremelimumab (T), ( anti-CTLA-4), was evaluated to determine activity in specific sarcoma subtypes (NCT02815995).