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Alexander J. Lazar
Researcher at University of Texas MD Anderson Cancer Center
Publications - 578
Citations - 55895
Alexander J. Lazar is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Sarcoma & Medicine. The author has an hindex of 93, co-authored 487 publications receiving 38717 citations. Previous affiliations of Alexander J. Lazar include Baylor College of Medicine & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
The Importance of Lymphovascular Invasion in Uterine Adenosarcomas: Analysis of Clinical, Prognostic, and Treatment Outcomes.
Michael J. Nathenson,Anthony P. Conley,Heather Lin,Nicole D. Fleming,Alexander J. Lazar,Wei Lien Wang,Vinod Ravi +6 more
TL;DR: The importance of LVI as a prognostic factor is highlighted and the prognostic significance of SO, MI, age, resection status, and FIGO stage for adenosarcoma is confirmed, suggesting that there is no additional benefit to adjuvant radiation.
Journal ArticleDOI
Heterogeneity and immunophenotypic plasticity of malignant cells in human liposarcomas.
Yan Zhang,Eric D. Young,Kate Lynn J. Bill,Roman Belousov,Tingsheng Peng,Alexander J. Lazar,Raphael E. Pollock,Paul J. Simmons,Dina Lev,Mikhail G. Kolonin +9 more
TL;DR: The results show that malignant cells in WDLS and DDLS can be classified according to distinct stages of adipogenesis and indicate immunophenotypic plasticity of malignant liposarcoma cells.
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Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma
Akash Mitra,Miles C. Andrews,Miles C. Andrews,Whijae Roh,Marianna Petaccia De Macedo,Courtney W. Hudgens,Fernando Carapeto,Shailbala Singh,Alexandre Reuben,Feng Wang,Xizeng Mao,Xingzhi Song,Khalida Wani,Samantha Tippen,Kwok Shing Ng,Aislyn Schalck,Donald A. Sakellariou-Thompson,Eveline Chen,Sangeetha M. Reddy,Christine N. Spencer,Diana H. Wiesnoski,Latasha Little,Curtis Gumbs,Zachary A. Cooper,Elizabeth M. Burton,Patrick Hwu,Michael A. Davies,Jianhua Zhang,Chantale Bernatchez,Nicholas Navin,Padmanee Sharma,James P. Allison,Jennifer A. Wargo,Cassian Yee,Michael T. Tetzlaff,Wen-Jen Hwu,Alexander J. Lazar,P. Andrew Futreal +37 more
TL;DR: An immunogenomic analysis on 67 intratumor sub-regions of a PD-1 inhibitor resistant melanoma, and 2 additional metastases from a single patient, mapping the spatial relationships between genomic and immune heterogeneity at high resolution is performed.
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Phase 1 adaptive dose-finding study of neoadjuvant gemcitabine combined with radiation therapy for patients with high-risk extremity and trunk soft tissue sarcoma.
William W. Tseng,William W. Tseng,Shouhao Zhou,Christina A. To,Peter F. Thall,Alexander J. Lazar,Raphael E. Pollock,Patrick P. Lin,Janice N. Cormier,Valerae O. Lewis,Barry W. Feig,Kelly K. Hunt,Matthew T. Ballo,Shreyaskumar Patel,Peter W.T. Pisters +14 more
TL;DR: This study was performed to determine the maximum tolerated dose (MTD) of gemcitabine given concurrently with preoperative, fixed‐dose external‐beam radiation therapy (EBRT) for patients with resectable, high‐risk extremity and trunk soft tissue sarcoma (STS).
Journal ArticleDOI
Utilization of cytology smears improves success rates of RNA-based next-generation sequencing gene fusion assays for clinically relevant predictive biomarkers
Nisha S. Ramani,Hui Chen,Russell Broaddus,Alexander J. Lazar,Rajyalakshmi Luthra,L. Jeffrey Medeiros,Keyur P. Patel,Asif Rashid,Mark J. Routbort,John Stewart,Zhenya Tang,Roland L. Bassett,Jawad Manekia,Bedia A. Barkoh,Hyvan Dang,Sinchita Roy-Chowdhuri +15 more
TL;DR: The authors evaluated the factors affecting RNA fusion testing in cytology and the added value of smears in cases with a suboptimal or inadequate CB and concluded that smears should be considered in addition to traditional smear tests in fusion testing cases.