V
Vedran Franke
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 45
Citations - 2295
Vedran Franke is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 22, co-authored 38 publications receiving 1579 citations. Previous affiliations of Vedran Franke include University of Zagreb & Friedrich Miescher Institute for Biomedical Research.
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Journal ArticleDOI
A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes
Matyas Flemr,Radek Malik,Vedran Franke,Jana Nejepinska,Radislav Sedlacek,Kristian Vlahoviček,Kristian Vlahoviček,Petr Svoboda +7 more
TL;DR: The alternative Dicer isoform, whose phylogenetic origin demonstrates evolutionary plasticity of RNA-silencing pathways, is the main determinant of endogenous RNAi activity in the mouse female germline.
Journal ArticleDOI
genomation: a toolkit to summarize, annotate and visualize genomic intervals
TL;DR: An R package, genomation, to expedite the extraction of biological information from high throughput data that works with a variety of genomic interval file types and enables easy summarization and annotation of high throughputData sets with given genomic annotations.
Journal ArticleDOI
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,Filippos Klironomos,David Koppstein,Katja Hönzke,Salah Ayoub,Christopher Buccitelli,Karen Hoffmann,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Samantha D. Praktiknjo,Thomas F. Meyer,Marcel A. Müller,Daniela Niemeyer,Andreas C. Hocke,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler,Markus Landthaler +29 more
TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.
Journal ArticleDOI
RNA localization is a key determinant of neurite-enriched proteome.
Alessandra Zappulo,David van den Bruck,Camilla Ciolli Mattioli,Vedran Franke,Koshi Imami,Erik McShane,Mireia Moreno-Estellés,Lorenzo Calviello,Andrei Filipchyk,Esteban Peguero-Sanchez,Esteban Peguero-Sanchez,Thomas Müller,Andrew Woehler,Carmen Birchmeier,Enrique Merino,Nikolaus Rajewsky,Uwe Ohler,Esteban O. Mazzoni,Matthias Selbach,Altuna Akalin,Marina Chekulaeva +20 more
TL;DR: The authors differentiate mouse embryonic stem cells into neurons, and analyze the local transcriptome, proteome, and translated transcriptome in their cell bodies and neurites, providing a unique resource for future studies on neuronal polarity.
Journal ArticleDOI
A cohesin-independent role for NIPBL at promoters provides insights in CdLS.
Jessica Zuin,Vedran Franke,Wilfred F. J. van IJcken,Antoine van der Sloot,Ian D. Krantz,Michael I.J.A. van der Reijden,Ryuichiro Nakato,Boris Lenhard,Kerstin S. Wendt +8 more
TL;DR: First, defects of NIPBL might lead to cohesin-loading defects and thereby alter gene expression and second, NipBL deficiency might affect genes directly via its role at the respective promoters.