A
Alexander Meissner
Researcher at Max Planck Society
Publications - 239
Citations - 69227
Alexander Meissner is an academic researcher from Max Planck Society. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 91, co-authored 227 publications receiving 62258 citations. Previous affiliations of Alexander Meissner include Broad Institute & Baylor College of Medicine.
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Journal ArticleDOI
Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis
Marlies P. Rossmann,Marlies P. Rossmann,Karen Hoi,Karen Hoi,Victoria Chan,Victoria Chan,Brian J. Abraham,Song Yang,James Mullahoo,Malvina Papanastasiou,Ying Wang,Ilaria Elia,Julie R. Perlin,Elliott J. Hagedorn,Sara Hetzel,Raha Weigert,Sejal Vyas,Partha P. Nag,Lucas B. Sullivan,Curtis R. Warren,Bilguujin Dorjsuren,Bilguujin Dorjsuren,Eugenia Custo Greig,Eugenia Custo Greig,Isaac Adatto,Isaac Adatto,Chad A. Cowan,Stuart L. Schreiber,Richard A. Young,Alexander Meissner,Alexander Meissner,Alexander Meissner,Marcia C. Haigis,Siegfried Hekimi,Steven A. Carr,Leonard I. Zon,Leonard I. Zon +36 more
TL;DR: In this paper, the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH) rescues erythroid differentiation in bloodless zebrafish moonshine (mon) mutant embryos defective for transcriptional intermediary factor 1 gamma (tif1γ).
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The simplest explanation: passive DNA demethylation in PGCs
TL;DR: Work by Saitou and colleagues presented in this issue of The EMBO Journal provide support for a simpler model whereby the downregulation of essential recruitment factors appears sufficient to erase this mark passively during a phase of rapid proliferation.
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Probabilistic Modeling of Reprogramming to Induced Pluripotent Stem Cells
Lin Liu,Justin Brumbaugh,Ori Bar-Nur,Zachary J. Smith,Matthias Stadtfeld,Alexander Meissner,Konrad Hochedlinger,Franziska Michor +7 more
TL;DR: This work developed an in silico analysis platform based on mathematical modeling that suggests that reprogramming driven by the Yamanaka factors alone is a more heterogeneous process, possibly due to cell-specific reprograming rates, which could be homogenized by the addition of additional factors.
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Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
Alessa R. Ringel,Quentin Szabo,Andrea M. Chiariello,Konrad Chudzik,Robert Schöpflin,Patricia Rothe,Alexandra L. Mattei,Tobias Zehnder,Dermot Harnett,Verena Laupert,Simona Bianco,Sara Hetzel,Juliane Glaser,M. Phan,M Schindler,Daniel M. Ibrahim,Christina Paliou,Andrea Esposito,Cesar Augusto Prada-Medina,Stefan A. Haas,Peter Giere,Martin Vingron,Lars Wittler,Alexander Meissner,Mario Nicodemi,Giacomo Cavalli,Frédéric Bantignies,Stefan Mundlos,Michael I. Robson +28 more
TL;DR: In this paper , the authors investigated how a placental mammal-specific gene, Zfp42, emerged in an ancient vertebrate topologically associated domain (TAD) without adopting or disrupting the conserved expression of its gene, Fat1.
Journal ArticleDOI
Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells.
Masaki Yagi,Fei Ji,Jocelyn Charlton,Jocelyn Charlton,Simona Cristea,Simona Cristea,Kathleen A. Messemer,Naftali Horwitz,Naftali Horwitz,Bruno Di Stefano,Nikolaos Tsopoulidis,Michael S. Hoetker,Aaron J. Huebner,Ori Bar-Nur,A. Almada,A. Almada,Masakazu Yamamoto,Anthony Patelunas,David J. Goldhamer,Amy J. Wagers,Amy J. Wagers,Franziska Michor,Alexander Meissner,Ruslan I. Sadreyev,Konrad Hochedlinger +24 more
TL;DR: In this article, the authors dissected the transcriptional and epigenetic dynamics of mouse fibroblasts undergoing reprogramming to either myotubes or iMPCs using a MyoD-inducible transgenic model.