A
Alexander Meissner
Researcher at Max Planck Society
Publications - 239
Citations - 69227
Alexander Meissner is an academic researcher from Max Planck Society. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 91, co-authored 227 publications receiving 62258 citations. Previous affiliations of Alexander Meissner include Broad Institute & Baylor College of Medicine.
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Journal ArticleDOI
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
Masaki Yagi,Masaki Yagi,Mio Kabata,Mio Kabata,Akito Tanaka,Tomoyo Ukai,Sho Ohta,Kazuhiko Nakabayashi,Masahito Shimizu,Kenichiro Hata,Alexander Meissner,Alexander Meissner,Alexander Meissner,Takuya Yamamoto,Yasuhiro Yamada +14 more
TL;DR: A set of unique de novo DNA methylation target sites for both DNMT3 enzymes during mammalian development that overlap with hypomethylated sites in human patients are reported.
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An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition
Peng Du,Peng Du,Mehdi Pirouz,Mehdi Pirouz,Jiho Choi,Aaron J. Huebner,Kendell Clement,Alexander Meissner,Konrad Hochedlinger,Richard I. Gregory +9 more
TL;DR: It is found that highly dynamic ISY1 expression during the naive-to-primed ESC transition defines a specific phase of "poised" pluripotency characterized by distinct miRNA and mRNA transcriptomes and widespread poised cell contribution to mouse chimeras.
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Transcriptional and Chromatin Dynamics of Muscle Regeneration After Severe Trauma
Carlos A. Aguilar,Ramona Pop,Ramona Pop,Anna Shcherbina,Alain Watts,Ronald W. Matheny,Davide Cacchiarelli,Davide Cacchiarelli,Woojin M. Han,Eunjung Shin,Shadi Nakhai,Young C. Jang,Christopher T. Carrigan,Casey A. Gifford,Casey A. Gifford,Melissa A. Kottke,Marcella Cesana,Jackson Lee,Maria L. Urso,Alexander Meissner,Alexander Meissner +20 more
TL;DR: A comprehensive view of the central factors that regulate muscle regeneration is provided and the multiple levels through which both transcriptional and epigenetic patterns are regulated to enact appropriate repair and regeneration are underscored.
Journal ArticleDOI
Age- and Pregnancy-Associated DNA Methylation Changes in Mammary Epithelial Cells
Sung Jin Huh,Sung Jin Huh,Kendell Clement,David Jee,David Jee,Alessandra Merlini,Alessandra Merlini,Sibgat Choudhury,Sibgat Choudhury,Reo Maruyama,Reo Maruyama,Ronnie Yoo,Ronnie Yoo,Anna Chytil,Patrick J Boyle,Fei Ann Ran,Fei Ann Ran,Harold L. Moses,Mary Helen Barcellos-Hoff,Laurie Jackson-Grusby,Laurie Jackson-Grusby,Alexander Meissner,Alexander Meissner,Kornelia Polyak +23 more
TL;DR: It is suggested that relatively minor changes in DNA methylation occur during luminal differentiation compared with the effects of pregnancy on CD24+CD61+CD29hi and CD24-CD61-CD29lo cells.
Journal ArticleDOI
X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs.
Vincent Pasque,Vincent Pasque,Rahul Karnik,Constantinos Chronis,Paula Petrella,Justin Langerman,Giancarlo Bonora,Juan Song,Lotte Vanheer,Anupama Sadhu Dimashkie,Alexander Meissner,Kathrin Plath +11 more
TL;DR: It is revealed that X chromosome dosage dictates global DNA methylation levels in iPSCs, and the loss of one of the two X chromosomes in propagating female iPSCS is associated with genome-wide methylation gain.