Alexander Rialdi

TL;DR: The data indicate that transcription elongation by RNA polymerase II remodels genome 3D architecture and affects cohesin-mediated chromatin contacts within gene bodies.

TL;DR: It is identified that inhibiting symmetric or asymmetric dimethylation of arginine, mediated by PRMT5 and type I proteinArginine methyltransferases (PRMTs), respectively, reduces splicing fidelity and results in preferential killing of SF-mutant leukemias over wild-type counterparts.

TL;DR: It is possible that the placenta tissue, but not umbilical cord blood, may be epigenetically programmed by maternal GDM, preeclampsia, and obesity to carry out its own specific functions that influence fetal growth.

TL;DR: It is demonstrated that local macrophage activation through dectin‐1 and toll‐like receptor 4 (TLR4) drives trained immunity‐associated cytokine production during allograft rejection and it is shown that HDL‐based nanoimmunotherapy can be employed to control Macrophage function in vivo.

TL;DR: MS1943 has a profound cytotoxic effect in multiple TNBC cells, while sparing normal cells, and is efficacious in vivo, suggesting that pharmacologic degradation of EZH2 can be advantageous for treating the cancers that are dependent on EZh2.