K
Kavita Mallya
Researcher at University of Nebraska Medical Center
Publications - 46
Citations - 6850
Kavita Mallya is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Pancreatic cancer & Metastasis. The author has an hindex of 18, co-authored 37 publications receiving 5081 citations. Previous affiliations of Kavita Mallya include Eppley Institute for Research in Cancer and Allied Diseases.
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Journal ArticleDOI
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino,Bruno Costa-Silva,Tang-Long Shen,Gonçalo Rodrigues,Ayako Hashimoto,Milica Tesic Mark,Henrik Molina,Shinji Kohsaka,Angela Di Giannatale,Sophia Ceder,Swarnima Singh,Caitlin Williams,Nadine Soplop,Kunihiro Uryu,Lindsay A. Pharmer,Tari A. King,Linda Bojmar,Alexander E. Davies,Yonathan Ararso,Tuo Zhang,Haiying Zhang,Jonathan M. Hernandez,Joshua Mitchell Weiss,Vanessa D. Dumont-Cole,Kimberly Kramer,Leonard H. Wexler,Aru Narendran,Gary K. Schwartz,John H. Healey,Per Sandström,Knut Jørgen Labori,Elin H. Kure,Paul M. Grandgenett,Michael A. Hollingsworth,Maria de Sousa,Sukwinder Kaur,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Mary S. Brady,Øystein Fodstad,Volkmar Müller,Klaus Pantel,Andy J. Minn,Mina J. Bissell,Benjamin A. Garcia,Yibin Kang,Yibin Kang,Vinagolu K. Rajasekhar,Cyrus M. Ghajar,Irina Matei,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +55 more
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
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Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva,Nicole M. Aiello,Allyson J. Ocean,Swarnima Singh,Haiying Zhang,Basant Kumar Thakur,Basant Kumar Thakur,Annette Becker,Ayuko Hoshino,Milica Tesic Mark,Henrik Molina,Jenny Xiang,Tuo Zhang,Till Martin Theilen,Guillermo García-Santos,Caitlin Williams,Yonathan Ararso,Yujie Huang,Gonçalo Rodrigues,Tang-Long Shen,Knut Jørgen Labori,Inger Marie Bowitz Lothe,Elin H. Kure,Jonathan M. Hernandez,Alexandre Doussot,Saya H. Ebbesen,Paul M. Grandgenett,Michael A. Hollingsworth,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Robert E. Schwartz,Irina Matei,Héctor Peinado,Ben Z. Stanger,Jacqueline Bromberg,David Lyden,David Lyden +38 more
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Journal ArticleDOI
Neural stem cell properties of Müller glia in the mammalian retina: regulation by Notch and Wnt signaling.
Ani V. Das,Kavita Mallya,Xing Zhao,Faraz Ahmad,Sumitra Bhattacharya,Wallace B. Thoreson,Ganapati V. Hegde,Iqbal Ahmad +7 more
TL;DR: It is shown that Müller cells, when retrospectively enriched from the normal retina, display cardinal features of neural stem cells (NSCs), i.e., they self-renew and generate all three basic cell types of the CNS.
Journal ArticleDOI
Transcriptional profiling of peripheral blood mononuclear cells in pancreatic cancer patients identifies novel genes with potential diagnostic utility.
Michael J. Baine,Subhankar Chakraborty,Lynette M. Smith,Kavita Mallya,Aaron R. Sasson,Randall E. Brand,Surinder K. Batra,Surinder K. Batra +7 more
TL;DR: The first in-depth comparison of global gene expression profiles of PBMCs between PC patients and healthy controls is reported, and an eight-gene predictor set is identified that could distinguish PC patients from healthy controls with an accuracy in a blinded subset of samples from treatment naïve patients.
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Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: Applications in diagnosis and therapy
María P. Torres,Satyanarayana Rachagani,Joshua J. Souchek,Kavita Mallya,Sonny L. Johansson,Surinder K. Batra,Surinder K. Batra +6 more
TL;DR: The successful establishment and characterization of three cell lines derived from two PDAC mouse models that mimic the genetic compendium of human PDAC make them valuable models with a high potential of translational relevance for examining diagnostic markers and therapeutic drugs.