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Alexandre E. Escargueil
Researcher at University of Paris
Publications - 62
Citations - 2751
Alexandre E. Escargueil is an academic researcher from University of Paris. The author has contributed to research in topics: Population & Cancer. The author has an hindex of 24, co-authored 59 publications receiving 2510 citations. Previous affiliations of Alexandre E. Escargueil include Institut Gustave Roussy & University of Oxford.
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Catalytic topoisomerase II inhibitors in cancer therapy.
TL;DR: A review of catalytic topoisomerase II poisons can be found in this paper, with an emphasis on therapeutically used compounds, such as Baccelli and novobiocin.
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Resistance mechanisms associated with altered intracellular distribution of anticancer agents.
TL;DR: The intracellular drug distribution is modified in many MDR cell lines, leading to increased drug sequestration in acidic vesicles, and a model proposed that suggests why these different resistance mechanisms are co-expressed in multiple cell lines is proposed.
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The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.
TL;DR: P-gp-mediated cholesterol redistribution in the cell membrane makes it likely that P-gp contributes in stabilizing the cholesterol-rich microdomains, rafts and caveolae, and that it is involved in the regulation of cholesterol trafficking in cells.
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Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743
Daniele G. Soares,Alexandre E. Escargueil,Virginie Poindessous,Alain Sarasin,Aimery de Gramont,Diego Bonatto,João Antonio Pêgas Henriques,Annette K. Larsen +7 more
TL;DR: The identification of DSB formation as a key step in the processing of ET-743 lesions represents a novel mechanism of action for the drug that is in agreement with its unusual potency.
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PARPs and the DNA damage response
Fabrício Garmus Sousa,Renata Matuo,Daniele G. Soares,Daniele G. Soares,Alexandre E. Escargueil,Alexandre E. Escargueil,João Antonio Pêgas Henriques,João Antonio Pêgas Henriques,Annette K. Larsen,Annette K. Larsen,Jenifer Saffi,Jenifer Saffi +11 more
TL;DR: The DDR functions of PARPs 1-3 and the emerging roles of poly (ADP ribose) polymers in DNA damage are reviewed and the development of PARP inhibitors, their applications and mechanisms of action are discussed in the context of the DDR.