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Annette K. Larsen
Researcher at Pierre-and-Marie-Curie University
Publications - 77
Citations - 3865
Annette K. Larsen is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Cancer & Topoisomerase. The author has an hindex of 34, co-authored 75 publications receiving 3501 citations. Previous affiliations of Annette K. Larsen include French Institute of Health and Medical Research & Massachusetts Institute of Technology.
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Journal ArticleDOI
Catalytic topoisomerase II inhibitors in cancer therapy.
TL;DR: A review of catalytic topoisomerase II poisons can be found in this paper, with an emphasis on therapeutically used compounds, such as Baccelli and novobiocin.
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Can Chemotherapy Be Discontinued in Unresectable Metastatic Colorectal Cancer? The GERCOR OPTIMOX2 Study
Benoist Chibaudel,F. Maindrault-Goebel,Gérard Lledo,Laurent Mineur,Thierry André,M. Bennamoun,May Mabro,Pascal Artru,Elisabeth Carola,M. Flesch,Olivier Dupuis,Philippe Colin,Annette K. Larsen,Pauline Afchain,Christophe Tournigand,Christophe Louvet,Aimery de Gramont +16 more
TL;DR: The planned complete discontinuation of chemotherapy had a negative impact on DDC and PFS compared with the maintenance therapy strategy, suggesting that chemotherapy discontinuation cannot be decided before therapy is initiated in patients with advanced colorectal cancer.
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Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Intissar Akalay,Bassam Janji,Meriem Hasmim,Muhammad Zaeem Noman,Fabrice Andre,Patricia de Cremoux,Philippe Bertheau,Cécile Badoual,Philippe Vielh,Annette K. Larsen,Michèle Sabbah,Tuan Zea Tan,Joan Herr Keira,Nicole Tsang Ying Hung,Jean Paul Thiery,Fathia Mami-Chouaib,Salem Chouaib +16 more
TL;DR: The results argue that in addition to promoting invasion and metastasis EMT also profoundly alters the susceptibility of cancer cells to T-cell-mediated immune surveillance, and reveal EMT and autophagy as conceptual realms for immunotherapeutic strategies to block immune escape.
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Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis.
Annette K. Larsen,Djamila Ouaret,Djamila Ouaret,Karima El Ouadrani,Karima El Ouadrani,Amélie Petitprez +5 more
TL;DR: Clinical application of new combinations should be preceded by preclinical development guided by functional biomarker analysis to identify active drug combinations and to facilitate the identification of patient subgroups likely, or not, to respond to dual pathway inhibition.
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Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743
Daniele G. Soares,Alexandre E. Escargueil,Virginie Poindessous,Alain Sarasin,Aimery de Gramont,Diego Bonatto,João Antonio Pêgas Henriques,Annette K. Larsen +7 more
TL;DR: The identification of DSB formation as a key step in the processing of ET-743 lesions represents a novel mechanism of action for the drug that is in agreement with its unusual potency.