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Eric S. Martinez
Researcher at University of California, Irvine
Publications - 3
Citations - 847
Eric S. Martinez is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Microglia & Retinoid X receptor. The author has an hindex of 3, co-authored 3 publications receiving 505 citations.
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Journal ArticleDOI
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Edsel M. Abud,Ricardo Ramirez,Eric S. Martinez,Luke M. Healy,Cecilia H.H. Nguyen,Sean A. Newman,Andriy V. Yeromin,Vanessa M. Scarfone,Samuel E. Marsh,Cristhian Fimbres,Chad A. Caraway,Gianna M. Fote,Abdullah M. Madany,Anshu Agrawal,Rakez Kayed,Karen H. Gylys,Michael D. Cahalan,Brian J. Cummings,Jack P. Antel,Ali Mortazavi,Monica J. Carson,Wayne W. Poon,Mathew Blurton-Jones +22 more
TL;DR: iMGLs were used to examine the effects of Aβ fibrils and brain-derived tau oligomers on AD-related gene expression and to interrogate mechanisms involved in synaptic pruning, and whole-transcriptome analysis demonstrates that they are highly similar to cultured adult and fetal human microglia.
Journal ArticleDOI
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.
Amanda McQuade,You Jung Kang,Jonathan Hasselmann,Amit Jairaman,Alexandra Sotelo,Morgan A. Coburn,Sepideh Kiani Shabestari,Jean Paul Chadarevian,Gianna M. Fote,Christina H. Tu,Emma Danhash,Jorge Silva,Eric S. Martinez,Carl W. Cotman,G. Aleph Prieto,G. Aleph Prieto,Leslie M. Thompson,Joan S. Steffan,Ian F. Smith,Hayk Davtyan,Michael D. Cahalan,Hansang Cho,Mathew Blurton-Jones +22 more
TL;DR: It is found that TREM2 deletion reduces microglial survival, impairs phagocytosis of key substrates including APOE, and inhibits SDF-1α/CXCR4-mediated chemotaxis, culminating in an impaired response to beta-amyloid plaques in vivo.
Journal ArticleDOI
Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage.
Bassem M. Shoucri,Eric S. Martinez,Timothy J Abreo,Victor T Hung,Zdena Moosova,Zdena Moosova,Toshi Shioda,Bruce Blumberg +7 more
TL;DR: It is shown that activation of RXR is sufficient for adipogenic commitment and that rexinoids act through RXR to alter the transcriptome in a manner favoring adipogenicity, and shed light on how endocrine‐disrupting chemicals such as TBT can reprogram stem cell fate.