A
Amir Sharafkhaneh
Researcher at Michael E. DeBakey Veterans Affairs Medical Center in Houston
Publications - 177
Citations - 6585
Amir Sharafkhaneh is an academic researcher from Michael E. DeBakey Veterans Affairs Medical Center in Houston. The author has contributed to research in topics: COPD & Obstructive sleep apnea. The author has an hindex of 36, co-authored 156 publications receiving 5720 citations. Previous affiliations of Amir Sharafkhaneh include University of Texas Health Science Center at Houston & United States Department of Veterans Affairs.
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Journal ArticleDOI
Toll-like Receptor 4 Is a Sensor for Autophagy Associated with Innate Immunity
Yi Xu,Chinnaswamy Jagannath,Xian De Liu,Amir Sharafkhaneh,Katarzyna E. Kolodziejska,N. Tony Eissa +5 more
TL;DR: It is shown that Toll-like receptor 4 (TLR4) served as a previously unrecognized environmental sensor for autophagy, and a new molecular pathway in which LPS-induced Autophagy was regulated through a Toll-interleukin-1 receptor domain-containing adaptor-inducing interferon-beta (TRIF)-dependent, myeloid differentiation factor 88 (MyD88)-independent TLR4 signaling pathway was defined.
Journal ArticleDOI
Association of psychiatric disorders and sleep apnea in a large cohort.
Amir Sharafkhaneh,Nilgun Giray,Nilgun Giray,Peter Richardson,Terry Young,Max Hirshkowitz,Max Hirshkowitz +6 more
TL;DR: Sleep apnea is associated with a higher prevalence of psychiatric comorbid conditions in Veterans Health Administration beneficiaries, and this association suggests that patients with psychiatric disorders and coincident symptoms suggesting sleep-disordered breathing should be evaluated for sleep apnea.
Journal ArticleDOI
A Comprehensive Care Management Program to Prevent Chronic Obstructive Pulmonary Disease Hospitalizations: A Randomized, Controlled Trial
Vincent S. Fan,J. Michael Gaziano,Robert A. Lew,Jean Bourbeau,Sandra G. Adams,Sarah Leatherman,Soe Soe Thwin,Grant D. Huang,Richard A. Robbins,P. S. Sriram,Amir Sharafkhaneh,M. Jeffery Mador,George A. Sarosi,Ralph J. Panos,Padmashri Rastogi,Todd H. Wagner,Steven A. Mazzuca,Colleen Shannon,Cindy Colling,Matthew H. Liang,James K. Stoller,Louis D. Fiore,Dennis E. Niewoehner +22 more
TL;DR: A comprehensive care management program (CCMP) in patients with severe COPD had not decreased COPD-related hospitalizations when the trial was stopped prematurely, and the CCMP was associated with unanticipated excess mortality.
Journal ArticleDOI
Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort.
Nicola A. Hanania,Hana Müllerová,Nicholas Locantore,Jørgen Vestbo,Jørgen Vestbo,Michael L. Watkins,Emiel F.M. Wouters,Stephen I. Rennard,Amir Sharafkhaneh,Amir Sharafkhaneh +9 more
TL;DR: Depression is more prevalent in subjects with COPD compared with smokers and nonsmokers without COPD and clinical and biologic measures were less important determinants of depression in COPD than disease symptoms and quality-of-life.
Journal ArticleDOI
Airway mucus: From production to secretion.
TL;DR: Recent advances in animal models and in vitro systems have provided a wealth of information regarding the identification of the mucin genes that are expressed in the lungs, the signal transduction pathways that regulate the expression of these mucins, and the secretory pathways that mediate their release into the airways.