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Christopher M. Evans
Researcher at University of Colorado Denver
Publications - 101
Citations - 7476
Christopher M. Evans is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Mucin & Mucus. The author has an hindex of 39, co-authored 94 publications receiving 6075 citations. Previous affiliations of Christopher M. Evans include University of Texas Health Science Center at Houston & Johns Hopkins University.
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Journal ArticleDOI
A common MUC5B promoter polymorphism and pulmonary fibrosis
Max A. Seibold,Anastasia L. Wise,Marcy C. Speer,Mark P. Steele,Kevin K. Brown,James E. Loyd,Tasha E. Fingerlin,Weiming Zhang,Gunnar Gudmundsson,Steve D. Groshong,Christopher M. Evans,Stavros Garantziotis,Kenneth B. Adler,Burton F. Dickey,Roland M. du Bois,Ivana V. Yang,Aretha Herron,Dolly Kervitsky,Janet Talbert,Cheryl Markin,Joungjoa Park,Anne L. Crews,Susan Slifer,Scott S. Auerbach,Michelle G. Roy,Jia Lin,Corinne E. Hennessy,Marvin I. Schwarz,David A. Schwartz +28 more
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
Journal ArticleDOI
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
Usha Chakravarthy,Tien Yin Wong,Tien Yin Wong,Astrid E. Fletcher,Elisabeth Piault,Christopher M. Evans,Gergana Zlateva,Ronald Buggage,Andreas M. Pleil,Paul Mitchell +9 more
TL;DR: Increasing age, current cigarette smoking, previous cataract surgery, and a family history of AMD showed strong and consistent associations with late AMD.
Journal ArticleDOI
Muc5b is required for airway defence
Michelle G. Roy,Alessandra Livraghi-Butrico,Ashley A. Fletcher,Melissa M. McElwee,Scott E. Evans,Ryan M. Boerner,Samantha N. Alexander,Lindsey K. Bellinghausen,Alfred S. Song,Youlia Petrova,Michael J. Tuvim,Roberto Adachi,Irlanda Romo,Andrea S. Bordt,M. Gabriela Bowden,M. Gabriela Bowden,Joseph H. Sisson,Prescott G. Woodruff,David J. Thornton,Karine Rousseau,Maria Miguelina De La Garza,Seyed Javad Moghaddam,Harry Karmouty-Quintana,Michael R. Blackburn,Scott M. Drouin,C. William Davis,Kristy A. Terrell,Barbara R. Grubb,Wanda K. O'Neal,Sonia C. Flores,Adela Cota-Gomez,Catherine A. Lozupone,Jody Donnelly,Alan M. Watson,Corinne E. Hennessy,Rebecca C. Keith,Ivana V. Yang,Lea Barthel,Peter M. Henson,William J. Janssen,David A. Schwartz,Richard C. Boucher,Burton F. Dickey,Christopher M. Evans,Christopher M. Evans +44 more
TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.
Journal ArticleDOI
Mucin Is Produced by Clara Cells in the Proximal Airways of Antigen-Challenged Mice
Christopher M. Evans,Olatunji W. Williams,Michael J. Tuvim,Rupesh Nigam,George P. Mixides,Michael R. Blackburn,Francesco J. DeMayo,Alan R. Burns,C. Smith,Susan D. Reynolds,Barry R. Stripp,Burton F. Dickey +11 more
TL;DR: Clara cells show great plasticity in structure and secretory products, yet have molecular and functional continuity in their identity as specialized apical secretory cells in mouse airway mucous cells.
Journal ArticleDOI
Airway mucus: From production to secretion.
TL;DR: Recent advances in animal models and in vitro systems have provided a wealth of information regarding the identification of the mucin genes that are expressed in the lungs, the signal transduction pathways that regulate the expression of these mucins, and the secretory pathways that mediate their release into the airways.