A
Andrea Marcellini
Researcher at University of Ferrara
Publications - 5
Citations - 274
Andrea Marcellini is an academic researcher from University of Ferrara. The author has contributed to research in topics: COPD & Rhinovirus. The author has an hindex of 4, co-authored 5 publications receiving 190 citations. Previous affiliations of Andrea Marcellini include National Institutes of Health.
Papers
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Journal ArticleDOI
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
Aran Singanayagam,Nicholas Glanville,Jason Girkin,Yee Man Ching,Andrea Marcellini,James D. Porter,Marie Toussaint,Ross P. Walton,Lydia J. Finney,Julia Aniscenko,Jie Zhu,Maria-Belen Trujillo-Torralbo,Maria Adelaide Calderazzo,Christopher Grainge,Su-Ling Loo,Punnam Chander Veerati,Prabuddha S. Pathinayake,Kristy Nichol,Andrew T. Reid,Phillip James,Roberto Solari,Peter A. B. Wark,Darryl A. Knight,Miriam F. Moffatt,William O.C.M. Cookson,Michael R. Edwards,Patrick Mallia,Nathan W. Bartlett,Nathan W. Bartlett,Sebastian L. Johnston +29 more
TL;DR: It is shown that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ, which raises suggestion that inhaled interferon-β therapy may protect.
Journal ArticleDOI
Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD
Marco Contoli,Alessia Pauletti,Maria Rita Rossi,Antonio Spanevello,Paolo Casolari,Andrea Marcellini,Giacomo Forini,Giulia Gnesini,Brunilda Marku,Neil Barnes,Neil Barnes,Andrea Rizzi,Giacomo Curradi,Gaetano Caramori,Paolo Morelli,Alberto Papi +15 more
TL;DR: Long-term inhaled corticosteroid treatment affects bacterial load in stable COPD, and lower eosinophil counts are associated with increased airway bacterial load.
Journal ArticleDOI
Phloridzin derivatives inhibiting pro-inflammatory cytokine expression in human cystic fibrosis IB3-1 cells.
Roberta Milani,Andrea Marcellini,Giulia Montagner,Anna Baldisserotto,Stefano Manfredini,Roberto Gambari,Ilaria Lampronti +6 more
TL;DR: In this article, Phloridzin tetrapropionate (F2) is shown to have the greatest potential as it demonstrates inhibitory effects on the expression and production of different cytokines involved in CF inflammation processes.
Journal ArticleDOI
Glucocorticoids impair type I IFN signalling and enhance rhinovirus replication.
Andrea Marcellini,Dawid Swieboda,Anabel Guedán,Stuart N. Farrow,Paolo Casolari,Marco Contoli,Sebastian L. Johnston,Alberto Papi,Roberto Solari +8 more
TL;DR: In this paper, the influence of glucocorticoid receptor (GCs) on viral replication was explored, showing that GCs significantly suppress pro-inflammatory (IL-6 and IL-8) and antiviral (IFN-λ1) cytokine production and the expression of interferon-stimulated genes (ISGs) OAS and viperin in RV-infected bronchial epithelial cells, with a consequent increase of viral replication.
Proceedings ArticleDOI
Role of the acetylcholine in the virus-induced bronchoconstriction
TL;DR: In bronchial epithelial cells Rhinovirus infection leads to the production of Acetylcholine via the activation of the enzyme choline acetyltransferase (CHAT), this induction is insensitive to the corticosteroids but is inhibited by Tiotropium.