J
James D. Porter
Researcher at National Institutes of Health
Publications - 4
Citations - 749
James D. Porter is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Rhinovirus & Asthma. The author has an hindex of 4, co-authored 4 publications receiving 595 citations. Previous affiliations of James D. Porter include Imperial College London.
Papers
More filters
Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations
Aran Singanayagam,Nicholas Glanville,Jason Girkin,Yee Man Ching,Andrea Marcellini,James D. Porter,Marie Toussaint,Ross P. Walton,Lydia J. Finney,Julia Aniscenko,Jie Zhu,Maria-Belen Trujillo-Torralbo,Maria Adelaide Calderazzo,Christopher Grainge,Su-Ling Loo,Punnam Chander Veerati,Prabuddha S. Pathinayake,Kristy Nichol,Andrew T. Reid,Phillip James,Roberto Solari,Peter A. B. Wark,Darryl A. Knight,Miriam F. Moffatt,William O.C.M. Cookson,Michael R. Edwards,Patrick Mallia,Nathan W. Bartlett,Nathan W. Bartlett,Sebastian L. Johnston +29 more
TL;DR: It is shown that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ, which raises suggestion that inhaled interferon-β therapy may protect.
Journal ArticleDOI
The role of macrolides in asthma: current evidence and future directions
TL;DR: The evidence from clinical trials is examined, macrolide properties and their relevance to the pathophysiology of asthma are discussed, and the use of macrolides in chronic asthma or acute exacerbations is not justified.
Journal ArticleDOI
Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium
James D. Porter,Jennifer Watson,Lee R. Roberts,Simren K. Gill,Helen T. Groves,Jaideep Dhariwal,Mark H. Almond,Ernie Wong,Ross P. Walton,Lyn H. Jones,John S. Tregoning,Iain Kilty,Sebastian L. Johnston,Michael R. Edwards +13 more
TL;DR: Evidence is provided that macrolides can be developed with anti-inflammatory, antibacterial and antiviral activity and show surprising versatility depending on the clinical need and the idea that macrology have antiviral properties through a mechanism that is yet to be ascertained is supported.