A
Andrea Ognibene
Researcher at I.O.R.
Publications - 52
Citations - 2708
Andrea Ognibene is an academic researcher from I.O.R.. The author has contributed to research in topics: Nuclear matrix & Emerin. The author has an hindex of 31, co-authored 52 publications receiving 2628 citations.
Papers
More filters
Journal ArticleDOI
The emerging multiple roles of nuclear Akt
Alberto M. Martelli,Alberto M. Martelli,Giovanna Tabellini,Daniela Bressanin,Andrea Ognibene,Kaoru Goto,Lucio Cocco,Camilla Evangelisti +7 more
TL;DR: Evidence accumulated over the past 15 years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways, and the most relevant findings about nuclear Akt are summarized.
Journal ArticleDOI
Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia
Francesca Chiarini,Cecilia Grimaldi,Francesca Ricci,Pier Luigi Tazzari,Camilla Evangelisti,Andrea Ognibene,Michela Battistelli,Elisabetta Falcieri,Fraia Melchionda,Andrea Pession,Pasqualepaolo Pagliaro,James A. McCubrey,Alberto M. Martelli +12 more
TL;DR: Results indicate that longitudinal inhibition at two nodes of the PI3K/Akt/mTOR network with NVP-BEZ235, either alone or in combination with chemotherapeutic drugs, may be an efficient treatment of those T-ALLs that have aberrant upregulation of this signaling pathway for their proliferation and survival.
Journal ArticleDOI
The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.
Alberto M. Martelli,Camilla Evangelisti,Francesca Chiarini,Cecilia Grimaldi,Alessandra Cappellini,Andrea Ognibene,James A. McCubrey +6 more
TL;DR: The evidence that links the signals emanating from the PI3K/Akt/mTOR cascade with the functions of hematopoietic stem cells and the process of myelopoiesis, including lineage commitment is reviewed.
Journal ArticleDOI
Collagen VI deficiency affects the organization of fibronectin in the extracellular matrix of cultured fibroblasts.
Patrizia Sabatelli,Paolo Bonaldo,Giovanna Lattanzi,Paola Braghetta,Natascha Bergamin,Cristina Capanni,Elisabetta Mattioli,Marta Columbaro,Andrea Ognibene,Guglielmina Pepe,Enrico Bertini,Luciano Merlini,Nadir M. Maraldi,Stefano Squarzoni +13 more
TL;DR: Results indicate that collagen VI mediates the three-dimensional organization of fibronectin in the extracellular matrix of cultured fibroblasts.
Journal ArticleDOI
Ataxin-3 is Transported Into the Nucleus and Associates with the Nuclear Matrix
Danilo Tait,Massimo Riccio,Annie Sittler,Eberhard Scherzinger,Spartaco Santi,Andrea Ognibene,Nadir M. Maraldi,Hans Lehrach,Erich E. Wanker +8 more
TL;DR: The results taken together with the finding of a nuclear localization signal in ataxin-3 indicate that the ataxIn-3 protein per se translocates to the nucleus and that an expanded glutamine repeat is not essential for this transport.