Institution
I.O.R.
About: I.O.R. is a based out in . It is known for research contribution in the topics: Protein kinase B & Cell culture. The organization has 115 authors who have published 127 publications receiving 3875 citations.
Topics: Protein kinase B, Cell culture, Nuclear matrix, Tumor necrosis factor alpha, PI3K/AKT/mTOR pathway
Papers published on a yearly basis
Papers
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TL;DR: The findings indicate that perifosine is a promising therapeutic agent for treatment of T-ALL cases characterized by both upregulation of the PI3K/Akt survival pathway and overexpression of P-gp.
Abstract: A significant impediment to the success of cancer chemotherapy is the occurrence of multidrug resistance, which, in many cases, is attributable to overexpression of membrane transport proteins, such as the 170-kDa P-glycoprotein (P-gp). Also, upregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway is known to play an important role in drug resistance, and has been implicated in the aggressiveness of a number of different cancers, including T-acute lymphoblastic leukemia (T-ALL). We have investigated the therapeutic potential of the novel Akt inhibitor, perifosine (a synthetic alkylphospholipid), on human T-ALL CEM cells (CEM-R), characterized by both overexpression of P-gp and constitutive upregulation of the PI3K/Akt network. Perifosine treatment induced death by apoptosis in CEM-R cells. Apoptosis was characterized by caspase activation, Bid cleavage and cytochrome c release from mitochondria. The proapoptotic effect of perifosine was in part dependent on the Fas/FasL interactions and c-Jun NH(2)-terminal kinase (JNK) activation, as well as on the integrity of lipid rafts. Perifosine downregulated the expression of P-gp mRNA and protein and this effect required JNK activity. Our findings indicate that perifosine is a promising therapeutic agent for treatment of T-ALL cases characterized by both upregulation of the PI3K/Akt survival pathway and overexpression of P-gp.
148 citations
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TL;DR: The evidence that links the signals emanating from the PI3K/Akt/mTOR cascade with the functions of hematopoietic stem cells and the process of myelopoiesis, including lineage commitment is reviewed.
141 citations
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TL;DR: In this article, the preparation of sol-gel films of hydroxyapatite, HA (Ca10(PO4)6(OH)2), on a titanium substrate is described.
Abstract: Biomaterials, in particular those used for orthopaedic prostheses, consist of a metallic substrate, exhibiting excellent mechanical properties, coated with a ceramic layer, which guarantees resistance to the corrosion and an elevated bioactivity. In this paper the preparation of sol-gel films of hydroxyapatite, HA (Ca10(PO4)6(OH)2), on titanium substrate is described. The samples were obtained through the dip-coating method, starting from a colloidal suspension of hydroxyapatite. In order to increase the adhesion between the HA film and the metallic substrate, the same substrate has been preliminarily coated either with titanium oxide, TiO2 (in the anatase or rutile phase), or calcium titanate, CaTiO3 (perovskite). Also these latter films have been deposited from a sol-gel solution. The characterization of the films through XRD, SEM, and AFM gave good results for the crystallinity of the deposited HA; for what concerns the sample morphology, the films turned out to be homogeneous and crack-free.
137 citations
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TL;DR: A new conduit made with a bioabsorbable copolymer, poly (L-lactide-co-6-caprolactone), was evaluated in an animal model as a guide for nerve regeneration, and nerve regeneration in the lumen was effective.
121 citations
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TL;DR: The results indicate that cells exposed to PMF for more than two hours have a significant clustering of the IMP distribution compared to control unexposed cells.
Abstract: Intramembrane proteins (IMP) represent a class of proteins located in the lipid bilayer of the cell membrane which function as ion channels, enzymes or receptors. Since it has been argued that biological effects of extremely low frequency (ELF) electromagnetic fields are mediated by plasma membrane. this work was designed to study the possible effects of 50 Hz pulsed magnetic fields (PMF) of the type used to stimulate bone repair, on the distribution of IMP in the plasma membrane of Swiss NIH 3T3 fibroblasts. Evaluations were based on the calculation of a distribution factor, which allows discrimination between random, regular and clustered distribution of IMP, in electron microscope images of freeze-fractured membranes. The results indicate that cells exposed to PMF for more than two hours have a significant clustering of the IMP distribution compared to control unexposed cells.
115 citations
Authors
Showing all 115 results
Name | H-index | Papers | Citations |
---|---|---|---|
Milena Fini | 72 | 565 | 18213 |
Alberto M. Martelli | 61 | 271 | 17659 |
Roberto Giardino | 58 | 279 | 11006 |
Gianluca Giavaresi | 57 | 320 | 10647 |
Andrea Facchini | 53 | 180 | 8247 |
Erminia Mariani | 49 | 167 | 7705 |
Nadir M. Maraldi | 44 | 169 | 6296 |
Patrizia Sabatelli | 41 | 127 | 6357 |
Spartaco Santi | 40 | 133 | 5176 |
Giovanna Lattanzi | 39 | 153 | 4559 |
Gianandrea Pasquinelli | 39 | 269 | 7098 |
Elisabetta Falcieri | 38 | 176 | 4915 |
Yolanda Gogorcena | 37 | 94 | 3390 |
Gina Lisignoli | 37 | 138 | 4361 |
Massimo Riccio | 37 | 70 | 3247 |