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Andreas G. Ladurner
Researcher at Ludwig Maximilian University of Munich
Publications - 97
Citations - 8634
Andreas G. Ladurner is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 43, co-authored 94 publications receiving 7723 citations. Previous affiliations of Andreas G. Ladurner include Center for Integrated Protein Science Munich & European Bioinformatics Institute.
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Journal ArticleDOI
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
M. Kozlowski,David Corujo,David Corujo,Michael Hothorn,Iva Guberovic,Imke K Mandemaker,Charlotte Blessing,Judith C. Sporn,Arturo Gutierrez‐Triana,Rebecca Smith,Thomas Portmann,Mathias Treier,Klaus Scheffzek,Sébastien Huet,Gyula Timinszky,Marcus Buschbeck,Andreas G. Ladurner,Andreas G. Ladurner +17 more
TL;DR: MacroH2A histone variants suppress tumor progression and act as epigenetic barriers to induced pluripotency and reduce the transient, PARP1‐dependent chromatin relaxation that occurs in living cells upon DNA damage through two distinct mechanisms.
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The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1
Stefania Dell'Orso,A. Hongjun Wang,Han-Yu Shih,Kayoko Saso,Libera Berghella,Gustavo Gutierrez-Cruz,Andreas G. Ladurner,John J. O'Shea,Vittorio Sartorelli,Hossein Zare +9 more
TL;DR: It is reported that mH2A1.2 is required for the activation of the myogenic gene regulatory network and muscle cell differentiation and a role is indicated in marking regulatory regions for activation of H3K27 acetylation at prospective enhancers and in imparting enhancer activation.
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MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD + consumption
Melanija Posavec Marjanović,Sarah Hurtado-Bagès,Sarah Hurtado-Bagès,Maximilian Lassi,Vanesa Valero,Roberto Malinverni,Hélène Delage,Miriam Navarro,David Corujo,Iva Guberovic,Julien Douet,Pau Gama-Perez,Pablo M. Garcia-Roves,Ivan Ahel,Andreas G. Ladurner,Oscar Yanes,Philippe Bouvet,Philippe Bouvet,Mònica Suelves,Raffaele Teperino,J. Andrew Pospisilik,Marcus Buschbeck +21 more
TL;DR: It is found that the metabolite-binding macrodomain was essential for sustained optimal mitochondrial function but dispensable for gene regulation, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity.
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Complementation of peptide fragments of the single domain protein chymotrypsin inhibitor 2
TL;DR: The folding of CI2 is extremely co-operative, and interactions have to be made between subdomains (1-40) and (41-64), consistent with the mechanism proposed for the folding pathway of intact CI2.
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Designing Cell-Type-Specific Genome-wide Experiments
TL;DR: The considerations needed when designing your own cell-type-specific experiment from the isolation of your starting material through selecting the appropriate controls and validating the data are discussed.