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Andrew B. Holmes
Researcher at University of Melbourne
Publications - 547
Citations - 43432
Andrew B. Holmes is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymer & Supercritical carbon dioxide. The author has an hindex of 75, co-authored 524 publications receiving 42062 citations. Previous affiliations of Andrew B. Holmes include University of Washington & Clare College.
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Atria display reduced conduction velocity and enhanced sensitivity to flecainide compared to ventricles
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An extremely mild acetate pyrolysis reaction. novel synthesis and x-ray structure determination of 1-azaspiro(5.5)undecane derivatives
Andrew B. Holmes,Paul R. Raithby,Keith Russell,Edward S. Stern,Michael E. Stubbs,Nicholas K. Wellard +5 more
TL;DR: In this paper, the azaspiro oxo-urethane (4), readily available from naphthalene, is reduced to the amino-alcohol whose diacetate (6), the structure of which was determined by X-ray crystallography, undergoes acetate elimination in refluxing toluene to yield the N-acetylazaspiroundecene (7).
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Participation of sulfonamide nitrogen in the rearrangement of the 2-azabicyclo(2.2.2)octane skeleton: an efficient synthesis of the 6-azabicyclo(3.2.1)octan-4-one system
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Synthesis of 4,4-Disubstituted Cyclohexenones. Part 3. The Reaction of 1,3-Bis(trimethylsilyloxy)cyclohexa-1,3-dienes with Dienophiles. An Unexpected Rearrangement of the Adducts from the Reaction with 2-Chloroacrylonitrile.
TL;DR: The cycloaddition of 2-chloroacrylonitrile to diene in toluene, hexane, or dichloromethane in the presence of Lewis acids such as Me2AlCl or TiCl4, occurs in high yield at −78 °C with great syn-selectivity and a slight preference for the exo-nitrile stereochemistry as discussed by the authors.
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Enantioselective Synthesis of (S)-γ-Acetylenic γ-Aminobutyric Acid (GABA) and (S)-trans-γ-Butenynyl GABA.
TL;DR: In this paper, the enantioselective syntheses of (S)-γ-acetylacetylenic γ-aminobutyric acid (GABA) and the (E)-butenynyl analogue (2) by phthalimide displacement of the homochiral prop-2-ynylic alcohols (6) and (11)[generated from the acetals (3, and (9, respectively], are reported.