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Andrew B. Holmes
Researcher at University of Melbourne
Publications - 547
Citations - 43432
Andrew B. Holmes is an academic researcher from University of Melbourne. The author has contributed to research in topics: Polymer & Supercritical carbon dioxide. The author has an hindex of 75, co-authored 524 publications receiving 42062 citations. Previous affiliations of Andrew B. Holmes include University of Washington & Clare College.
Papers
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Journal ArticleDOI
Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels.
Sian O' Brien,Andrew B. Holmes,Daniel M. Johnson,S. Nashitha Kabir,C. O' Shea,Molly O' Reilly,Adelisa Avezzù,Jasmeet S. Reyat,Amelia W. Hall,Clara Apicella,Patrick T. Ellinor,Steven A. Niederer,Nathan R. Tucker,Larissa Fabritz,Paulus Kirchhof,Davor Pavlovic +15 more
TL;DR: In this article , the authors demonstrate intrinsic differences between atrial and ventricular cardiac voltage-gated sodium currents (INa), leading to reduced maximum upstroke velocity of action potential and slower conduction, in left atria compared to ventricle.
Proceedings ArticleDOI
New family of polyfluorene copolymers for light emitting devices
Andrew B. Holmes,T Sano,Cédric Fischmeister,Joseph Frey,Ulrich Hennecke,Chi Shen Tuan,Beng Sim Chuah,Yuguang Ma,Rainer E. Martin,Ian D. Rees,Jian Li,Neil Feeder,Andrew D. Bond,Franco Cacialli,Shuang Fang Lim,Richard H. Friend +15 more
TL;DR: Poly(2,3-dibutoxy- 1,4-phenylenevinylene) is a protoypical conjugated polymer which is thought to derive its high PL solid state fluorescence efficiency from the sterically twisted backbone and devices carrying this polymer have been further evaluated as discussed by the authors.
Journal ArticleDOI
High resolution optical mapping of cardiac electrophysiology in pre-clinical models
Christopher O’Shea,James Winter,S. Nashitha Kabir,Molly O’Reilly,S. Wells,Olivia Baines,L C Sommerfeld,Joao Correia,M. Lei,Paulus Kirchhof,Andrew B. Holmes,Larissa Fabritz,Kashif Rajpoot,Davor Pavlovic +13 more
TL;DR: In this paper , the authors have generated a comprehensive post-processed dataset characterising the baseline cardiac electrophysiology in these widely used pre-clinical models, providing reference information detailing the effect of heart rate, clinically used antiarrhythmic drugs, ischaemia-reperfusion and sympathetic nervous stimulation.
Journal ArticleDOI
Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?
Andrew B. Holmes,Agnieszka Swiderska,Demitris Nathanael,Hayyaf S. Aldossary,Clare J. Ray,Andrew M. Coney,Prem Kumar +6 more
TL;DR: There is unlikely to be a single mechanism, but instead multiple mitochondrial related signalling pathways are recruited at different PaO2s during hypoxia, and it still remains to be determined if mitochondrial signalling acts independently or in partnership with extra-mitochondrial O2-sensors.
Effect of the Sampling Parameters in FOCV-MPPT Circuits for Fast-Varying EH Sources
TL;DR: In this paper , the influence of sampling time and period on the harvested power of sinusoidal EH sources was theoretically analyzed, and the circuit limitations to achieve a fast sampling rate were presented and circuits to deal with them proposed and implemented.