A
Andrew R. Crowley
Researcher at Dartmouth College
Publications - 25
Citations - 590
Andrew R. Crowley is an academic researcher from Dartmouth College. The author has contributed to research in topics: Antibody & Effector. The author has an hindex of 12, co-authored 19 publications receiving 301 citations. Previous affiliations of Andrew R. Crowley include University of Massachusetts Medical School.
Papers
More filters
Journal ArticleDOI
Distinct Features and Functions of Systemic and Mucosal Humoral Immunity Among SARS-CoV-2 Convalescent Individuals.
Savannah E. Butler,Andrew R. Crowley,Harini Natarajan,Shiwei Xu,Joshua A. Weiner,Carly A. Bobak,Daniel E Mattox,Jiwon Lee,Wendy Wieland-Alter,Ruth I Connor,Peter F. Wright,Margaret E. Ackerman +11 more
TL;DR: In this article, the authors report systemic and mucosal antibody responses in convalescent individuals who experienced varying severity of disease, finding that robust neutralization and phagocytosis were apparent in nasal wash samples, while mucosal neutralization was associated with nasal SARS-CoV-2-specific IgA.
Journal ArticleDOI
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.
William R. Morgenlander,Stephanie N. Henson,Daniel R. Monaco,Athena Chen,Kirsten Littlefield,Evan M. Bloch,Eric Fujimura,Ingo Ruczinski,Andrew R. Crowley,Harini Natarajan,Savannah E. Butler,Joshua A. Weiner,Mamie Z. Li,Tania S. Bonny,Sarah E. Benner,Ashwin Balagopal,David Sullivan,David Sullivan,Shmuel Shoham,Thomas C. Quinn,Thomas C. Quinn,Susan H. Eshleman,Arturo Casadevall,Andrew D. Redd,Andrew D. Redd,Oliver Laeyendecker,Oliver Laeyendecker,Margaret E. Ackerman,Andrew Pekosz,Stephen J. Elledge,Matthew L Robinson,Aaron A.R. Tobian,H. Benjamin Larman +32 more
TL;DR: In this article, the authors assessed antibody functionality and reactivities to peptides across the CoV2 and the 4 endemic human coronavirus (HCoV) genomes in 126 CCP donations.
Journal ArticleDOI
IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.
Simone I. Richardson,Bronwen E. Lambson,Andrew R. Crowley,Arman Bashirova,Cathrine Scheepers,Nigel Garrett,Nigel Garrett,Salim S. Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Nonhlanhla N. Mkhize,Mary Carrington,Margaret E. Ackerman,Penny L. Moore,Penny L. Moore,Lynn Morris,Lynn Morris +16 more
TL;DR: This study showed that co-operation between the variable and natural IgG3 constant regions enhanced the polyfunctionality of antibodies, indicating the value of leveraging genetic variation which could be exploited for passive immunity.
Journal ArticleDOI
Mind the Gap: How Interspecies Variability in IgG and Its Receptors May Complicate Comparisons of Human and Non-human Primate Effector Function.
TL;DR: A guide to translations that encompasses not only what is presently known regarding the affinity of the receptor-ligand interactions but also the influence of expression patterns and allelic variation, with a focus on insights gained from use of this model in HIV vaccines and passive antibody therapy and treatment.
Journal ArticleDOI
Fc-mediated effector function contributes to the in vivo antiviral effect of an HIV neutralizing antibody.
Mangaiarkarasi Asokan,Joana Dias,Cuiping Liu,Anna Maximova,Keenan Ernste,Amarendra Pegu,Krisha McKee,Wei Shi,Xuejun Chen,Cassandra G Almasri,Wanwisa Promsote,David R. Ambrozak,Lucio Gama,Jianfei Hu,Daniel C. Douek,John-Paul Todd,Jeffrey D. Lifson,Slim Fourati,Rafick Pierre Sekaly,Andrew R. Crowley,Margaret E. Ackerman,Sung Hee Ko,Divya Kilam,Eli Boritz,Laura E. Liao,Katharine Best,Alan S. Perelson,John R. Mascola,Richard A. Koup +28 more
TL;DR: The studies show that the predominant mechanism of antiviral activity of HIV NAbs is through inhibition of viral entry, but that Fc function can contribute to the overall antiviralActivity, making them distinct from standard ARVs.