A
Andrew Williams
Researcher at University of Pennsylvania
Publications - 6
Citations - 222
Andrew Williams is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cognition & Mitophagy. The author has an hindex of 4, co-authored 5 publications receiving 145 citations.
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Journal ArticleDOI
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders
David G. Coughlin,Sharon X. Xie,Mendy Liang,Andrew Williams,Claire Peterson,Daniel Weintraub,Daniel Weintraub,Corey T. McMillan,David A. Wolk,Rizwan S. Akhtar,Howard I. Hurtig,H. Branch Coslett,Roy H. Hamilton,Andrew Siderowf,John E. Duda,John E. Duda,Katya Rascovsky,Edward B. Lee,Virginia M.-Y. Lee,Murray Grossman,John Q. Trojanowski,David J. Irwin +21 more
TL;DR: Using digital histology in a large autopsy cohort of Lewy body disorder patients with dementia to test the hypotheses that co‐occurring Alzheimer disease pathology impacts the anatomic distribution of α‐synuclein (SYN) pathology and that co-occurring neocortical tau pathology in LBDs associates with worse cognitive performance and occurs in a pattern differing from AD.
Journal ArticleDOI
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations
C Liao,Neil Ashley,Alan Diot,Karl J. Morten,Kanchan Phadwal,Andrew Williams,Ian M. Fearnley,Lyndon Rosser,J Lowndes,Carl Fratter,David J. P. Ferguson,Laura Vay,Gerardine Quaghebeur,Isabella Moroni,Stefania Bianchi,Costanza Lamperti,Susan M. Downes,Kamil S. Sitarz,Padraig J. Flannery,Janet Carver,Eszter Dombi,Daniel A. East,Matilde Laura,Mary M. Reilly,Heather Mortiboys,Remko Prevo,Michelangelo Campanella,Matthew J. Daniels,Massimo Zeviani,Patrick Yu-Wai-Man,Anna Katharina Simon,Marcela Votruba,Joanna Poulton +32 more
TL;DR: Excessive mitochondrial fragmentation, dysregulated mitophagy, and impaired response to energetic stress in the pathogenesis of mitochondrial optic neuropathies, potentially linked with mitochondrial mislocalization and mtDNA depletion are demonstrated.
Journal ArticleDOI
Divergent patterns of TDP-43 and tau pathologies in primary progressive aphasia.
Lucia A. A. Giannini,Lucia A. A. Giannini,Sharon X. Xie,Corey T. McMillan,Mendy Liang,Andrew Williams,Charles Jester,Katya Rascovsky,David A. Wolk,Sharon Ash,Edward B. Lee,John Q. Trojanowski,Murray Grossman,David J. Irwin +13 more
TL;DR: To measure postmortem burden of frontotemporal lobar degeneration with TDP‐43 (FTLD‐TDP) or tau (FT LD‐Tau) proteinopathy across hemispheres in primary progressive aphasia (PPA) using digital histopathology and to identify clinicopathological correlates of these distinct proteinopathies.
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Occupational attainment influences longitudinal decline in behavioral variant frontotemporal degeneration.
Lauren Massimo,Sharon X. Xie,Lior Rennert,Donna M. Fick,Amy Halpin,Katerina Placek,Andrew Williams,Katya Rascovsky,David J. Irwin,Murray Grossman,Corey T. McMillan +10 more
TL;DR: The longitudinal findings suggest that bvFTD individuals with higher lifetime cognitive experience demonstrate more rapid decline on measures of executive function, and this finding converges with cross-sectional evidence suggesting that lifetime cognitive experiences contribute to heterogeneity in clinical progression in bv FTD.
Journal ArticleDOI
Dysregulated mitophagy and mitochondrial transport in severe dominant optic atrophy due to OPA1 mutations
C Liao,Neil Ashley,Karl J. Morten,Kanchan Phadwal,Andrew Williams,Ian M. Fearnley,L Rosser,J Lowndes,Carl Fratter,David J. P. Ferguson,Laura Vay,Gerardine Quaghebeur,L Macleod,A. Gabriel,Susan M. Downes,K. Simon,Marcela Votruba,Joanna Poulton +17 more