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Andriy V. Yeromin
Researcher at University of California, Irvine
Publications - 18
Citations - 5266
Andriy V. Yeromin is an academic researcher from University of California, Irvine. The author has contributed to research in topics: ORAI1 & STIM2. The author has an hindex of 14, co-authored 16 publications receiving 4828 citations. Previous affiliations of Andriy V. Yeromin include University of California.
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
Journal ArticleDOI
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
Shenyuan L. Zhang,Andriy V. Yeromin,Xiang Zhang,Ying Yu,Olga Safrina,Aubin Penna,Jack Roos,Kenneth A. Stauderman,Michael D. Cahalan +8 more
TL;DR: Using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, 75 hits are identified that strongly inhibited Ca(2+) influx upon store emptying by thapsigargin, including Stim and olf186-F, a member of a highly conserved family of four-transmembrane spanning proteins with homologs from Caenorhabditis elegans to human.
Journal ArticleDOI
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
Andriy V. Yeromin,Shenyuan L. Zhang,Shenyuan L. Zhang,Weihua Jiang,Weihua Jiang,Ying Yu,Ying Yu,Olga Safrina,Olga Safrina,Michael D. Cahalan,Michael D. Cahalan +10 more
TL;DR: By site-directed mutagenesis, it is shown that a point mutation from glutamate to aspartate at position 180 in the conserved S1–S2 loop of Orai transforms the ion selectivity properties of CRAC current from being Ca2+-selective with inward rectification to being selective for monovalent cations and outwardly rectifying.
Journal ArticleDOI
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Edsel M. Abud,Ricardo Ramirez,Eric S. Martinez,Luke M. Healy,Cecilia H.H. Nguyen,Sean A. Newman,Andriy V. Yeromin,Vanessa M. Scarfone,Samuel E. Marsh,Cristhian Fimbres,Chad A. Caraway,Gianna M. Fote,Abdullah M. Madany,Anshu Agrawal,Rakez Kayed,Karen H. Gylys,Michael D. Cahalan,Brian J. Cummings,Jack P. Antel,Ali Mortazavi,Monica J. Carson,Wayne W. Poon,Mathew Blurton-Jones +22 more
TL;DR: iMGLs were used to examine the effects of Aβ fibrils and brain-derived tau oligomers on AD-related gene expression and to interrogate mechanisms involved in synaptic pruning, and whole-transcriptome analysis demonstrates that they are highly similar to cultured adult and fetal human microglia.
Journal ArticleDOI
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
Aubin Penna,Angelo Demuro,Andriy V. Yeromin,Shenyuan L. Zhang,Olga Safrina,Ian Parker,Michael D. Cahalan +6 more
TL;DR: It is shown that Orai is predominantly a dimer in the plasma membrane under resting conditions, which represents a new mechanism in which assembly and activation of the functional ion channel are mediated by the same triggering molecule.