M
Monica J. Carson
Researcher at University of California, Riverside
Publications - 75
Citations - 10390
Monica J. Carson is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 37, co-authored 72 publications receiving 8439 citations. Previous affiliations of Monica J. Carson include Scripps Research Institute & Wistar Institute.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
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CNS immune privilege: hiding in plain sight
TL;DR: This newer view of CNS immune privilege is opening the door for therapies designed to harness autoreactive lymphocyte responses and implies that CNS autoimmune diseases (i.e. multiple sclerosis) may result as much from neuronal and/or glial dysfunction as from immune system dysfunctions.
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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Edsel M. Abud,Ricardo Ramirez,Eric S. Martinez,Luke M. Healy,Cecilia H.H. Nguyen,Sean A. Newman,Andriy V. Yeromin,Vanessa M. Scarfone,Samuel E. Marsh,Cristhian Fimbres,Chad A. Caraway,Gianna M. Fote,Abdullah M. Madany,Anshu Agrawal,Rakez Kayed,Karen H. Gylys,Michael D. Cahalan,Brian J. Cummings,Jack P. Antel,Ali Mortazavi,Monica J. Carson,Wayne W. Poon,Mathew Blurton-Jones +22 more
TL;DR: iMGLs were used to examine the effects of Aβ fibrils and brain-derived tau oligomers on AD-related gene expression and to interrogate mechanisms involved in synaptic pruning, and whole-transcriptome analysis demonstrates that they are highly similar to cultured adult and fetal human microglia.
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Insulin-like growth factor I increases brain growth and central nervous system myelination in tTransgenic mice
TL;DR: It is shown that IGF-I is a potent inducer of brain growth and myelination in vivo and that the brains of transgenic mice were 55% larger than those of controls owing to an increase in cell size and apparently in cell number.
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Mature microglia resemble immature antigen‐presenting cells
TL;DR: Comparing the phenotypes of murine microglia isolated from adults, neonates, and from mixed glial cultures with spleen cells withSpleen cells from fetuses, neonate, and adults suggests that adult microglian remain in a relatively immature and unactivated state of differentiation as compared to other tissue macrophages.