C
Chad A. Caraway
Researcher at University of California, Irvine
Publications - 8
Citations - 863
Chad A. Caraway is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Genetic association & Lewy body. The author has an hindex of 4, co-authored 6 publications receiving 495 citations. Previous affiliations of Chad A. Caraway include University of Turin.
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Journal ArticleDOI
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
Edsel M. Abud,Ricardo Ramirez,Eric S. Martinez,Luke M. Healy,Cecilia H.H. Nguyen,Sean A. Newman,Andriy V. Yeromin,Vanessa M. Scarfone,Samuel E. Marsh,Cristhian Fimbres,Chad A. Caraway,Gianna M. Fote,Abdullah M. Madany,Anshu Agrawal,Rakez Kayed,Karen H. Gylys,Michael D. Cahalan,Brian J. Cummings,Jack P. Antel,Ali Mortazavi,Monica J. Carson,Wayne W. Poon,Mathew Blurton-Jones +22 more
TL;DR: iMGLs were used to examine the effects of Aβ fibrils and brain-derived tau oligomers on AD-related gene expression and to interrogate mechanisms involved in synaptic pruning, and whole-transcriptome analysis demonstrates that they are highly similar to cultured adult and fetal human microglia.
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Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture
Ruth Chia,Marya S. Sabir,Sara Bandres-Ciga,Sara Saez-Atienzar,Regina H. Reynolds,Regina H. Reynolds,Regina H. Reynolds,Emil K. Gustavsson,Emil K. Gustavsson,Ronald L. Walton,Samreen Ahmed,Coralie Viollet,Jinhui Ding,Mary B. Makarious,Monica Diez-Fairen,Makayla K. Portley,Zalak Shah,Yevgeniya Abramzon,Yevgeniya Abramzon,Dena G. Hernandez,Cornelis Blauwendraat,David J. Stone,John D. Eicher,Laura Parkkinen,Olaf Ansorge,Lorraine N. Clark,Lawrence S. Honig,Karen Marder,Afina W. Lemstra,Peter St George-Hyslop,Peter St George-Hyslop,Elisabet Londos,Kevin Morgan,Tammaryn Lashley,Thomas T. Warner,Zane Jaunmuktane,Douglas Galasko,Isabel Santana,Pentti J. Tienari,Liisa Myllykangas,Minna Oinas,Nigel J. Cairns,John C. Morris,Glenda M. Halliday,Vivianna M. Van Deerlin,John Q. Trojanowski,Maurizio Grassano,Maurizio Grassano,Andrea Calvo,Gabriele Mora,Antonio Canosa,Gianluca Floris,Ryan C. Bohannan,Francesca Brett,Ziv Gan-Or,Joshua T. Geiger,Anni Moore,Patrick May,Rejko Krüger,Rejko Krüger,David S. Goldstein,Grisel Lopez,Nahid Tayebi,Ellen Sidransky,Lucy Norcliffe-Kaufmann,Jose-Alberto Palma,Horacio Kaufmann,Vikram G. Shakkottai,Matthew H. Perkins,Kathy L. Newell,Thomas Gasser,Claudia Schulte,Francesco Landi,Erika Salvi,Daniele Cusi,Eliezer Masliah,Ronald C. Kim,Chad A. Caraway,Edwin S. Monuki,Maura Brunetti,Ted M. Dawson,Liana S. Rosenthal,Marilyn S. Albert,Olga Pletnikova,Juan C. Troncoso,Margaret E. Flanagan,Qinwen Mao,Eileen H. Bigio,Eloy Rodríguez-Rodríguez,Jon Infante,Carmen Lage,Isabel González-Aramburu,Pascual Sánchez-Juan,Bernardino Ghetti,Julia Keith,Sandra E. Black,Mario Masellis,Ekaterina Rogaeva,Charles Duyckaerts,Alexis Brice,Suzanne Lesage,Georgia Xiromerisiou,Matthew J. Barrett,Bension S. Tilley,Steve M. Gentleman,Giancarlo Logroscino,Geidy E. Serrano,Thomas G. Beach,Ian G. McKeith,Alan J. Thomas,Johannes Attems,Christopher Morris,Laura Palmer,Seth Love,Claire Troakes,Safa Al-Sarraj,Angela Hodges,Dag Aarsland,Dag Aarsland,Gregory Klein,Scott M. Kaiser,Randy Woltjer,Pau Pastor,Lynn M. Bekris,James B. Leverenz,Lilah M. Besser,Amanda B. Kuzma,Alan E. Renton,Alison Goate,David A. Bennett,Clemens R. Scherzer,Huw R. Morris,Raffaele Ferrari,Diego Albani,Stuart Pickering-Brown,Kelley Faber,Walter A. Kukull,Estrella Morenas-Rodríguez,Estrella Morenas-Rodríguez,Alberto Lleó,Juan Fortea,Daniel Alcolea,Jordi Clarimón,Mike A. Nalls,Luigi Ferrucci,Susan M. Resnick,Toshiko Tanaka,Tatiana Foroud,Neill R. Graff-Radford,Zbigniew K. Wszolek,Tanis J. Ferman,Bradley F. Boeve,John Hardy,Eric J. Topol,Ali Torkamani,Andrew B. Singleton,Mina Ryten,Mina Ryten,Dennis W. Dickson,Adriano Chiò,Owen A. Ross,J. Raphael Gibbs,Clifton L. Dalgard,Bryan J. Traynor,Bryan J. Traynor,Bryan J. Traynor,Sonja W. Scholz +166 more
TL;DR: This article performed whole-genome sequencing in large cohorts of Lewy body dementia (LBD) cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community.
Journal ArticleDOI
Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients
Christopher Duma,Oleg V. Kopyov,Alex Kopyov,Mark Berman,Elliot B Lander,Michael Elam,Michael Arata,David Weiland,Ruslana Cannell,Chad A. Caraway,Sean Berman,Kristin Scord,Lian Stemler,Karlyssa Chung,Samuel Khoudari,Rory McRory,Chace Duma,Sawyer Farmer,Anthony Bravo,Christian Yassa,Ami R Sanathara,Elisa Singh,Benjamin Rapaport +22 more
TL;DR: Primary endpoints of clinical improvement or stability were particularly promising in the AD and MS-P groups, and ADSVF was safely injected into the human brain ventricular system in patients with no other treatment options.
Journal ArticleDOI
Upfront boost Gamma Knife "leading-edge" radiosurgery to FLAIR MRI-defined tumor migration pathways in 174 patients with glioblastoma multiforme: a 15-year assessment of a novel therapy.
Christopher Duma,Brian S. Kim,Peter Chen,Marianne Plunkett,Ralph Mackintosh,Marlon S. Mathews,Ryan M Casserly,Gustavo Mendez,Daniel J Furman,Garrett Smith,Nathan Oh,Chad A. Caraway,Ami R Sanathara,Robert O. Dillman,Azzurra-Sky Riley,David Weiland,Lian Stemler,Ruslana Cannell,Daniela Alexandru Abrams,Alexa Smith,Christopher M Owen,Burton L. Eisenberg,Michael Brant-Zawadzki +22 more
TL;DR: LERS is a safe and effective upfront adjunctive therapy for patients with newly diagnosed GBM with single-fraction stereotactic radiosurgery as a boost to standard therapy and a multicenter trial will further elucidate its value in the treatment of GBM.
Journal ArticleDOI
Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches
TL;DR: This review includes a variety of polymeric NPs and how their associated composition, surface modifications, and method of delivery impact their capacity to improve brain tumor therapy.