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Andrzej T. Wierzbicki
Researcher at University of Michigan
Publications - 40
Citations - 3389
Andrzej T. Wierzbicki is an academic researcher from University of Michigan. The author has contributed to research in topics: Chromatin & RNA polymerase V. The author has an hindex of 20, co-authored 32 publications receiving 3017 citations. Previous affiliations of Andrzej T. Wierzbicki include Washington University in St. Louis & University of Warsaw.
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Journal ArticleDOI
Noncoding transcription by RNA polymerase Pol IVb/Pol V mediates transcriptional silencing of overlapping and adjacent genes.
TL;DR: Arabidopsis RNA polymerase IVb/Pol V, a multisubunit nuclear enzyme required for siRNA-mediated gene silencing of transposons and other repeats, transcribes intergenic and noncoding sequences, thereby facilitating heterochromatin formation andsilencing of overlapping and adjacent genes.
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RNA polymerase V transcription guides ARGONAUTE4 to chromatin
TL;DR: The data suggest that AGO4 is guided to target loci through base-pairing of associated siRNAs with nascent Pol V transcripts, and that DEFECTIVE in MERISTEM SILENCING3, a structural maintenance of chromosomes (SMC) hinge-domain protein, functions in the assembly of Pol V transcription initiation or elongation complexes.
Journal ArticleDOI
Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II
Thomas S. Ream,Jeremy R. Haag,Andrzej T. Wierzbicki,Carrie D. Nicora,Angela D. Norbeck,Jian-Kang Zhu,Gretchen Hagen,Tom J. Guilfoyle,Ljiljana Paša-Tolić,Craig S. Pikaard +9 more
TL;DR: The hypothesis that Pol IV and Pol V are Pol II-like enzymes that evolved specialized roles in the production of noncoding transcripts for RNA silencing and genome defense is supported.
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An effector of RNA-directed DNA methylation in Arabidopsis is an ARGONAUTE 4- and RNA-binding protein
Xin-Jian He,Yi-Feng Hsu,Yi-Feng Hsu,Shihua Zhu,Shihua Zhu,Andrzej T. Wierzbicki,Olga Pontes,Craig S. Pikaard,Hailiang Liu,Co-Shine Wang,Hailing Jin,Jian-Kang Zhu +11 more
TL;DR: The results suggest KTF1 as an adaptor protein that binds scaffold transcripts generated by Pol V and recruits AGO 4 and AGO4-bound siRNAs to form an RdDM effector complex, a general feature of RNA-silencing effector complexes.
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Control of Chromatin Structure by Long Noncoding RNA
TL;DR: Evidence showing that lncRNA also controls chromatin structure, including nucleosome positioning and chromosome looping is summarized and it is proposed that the unique properties of RNA make it suitable for controlling chromatin modifications and structure.