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Angela Cheverton
Researcher at Wellcome Trust Sanger Institute
Publications - 2
Citations - 1839
Angela Cheverton is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Exome & Somatic evolution in cancer. The author has an hindex of 2, co-authored 2 publications receiving 1678 citations. Previous affiliations of Angela Cheverton include Wellcome Trust.
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Journal ArticleDOI
The landscape of cancer genes and mutational processes in breast cancer
Philip J. Stephens,Patrick S. Tarpey,Helen Davies,Peter Van Loo,Peter Van Loo,Christopher Greenman,Christopher Greenman,David C. Wedge,Serena Nik-Zainal,Sancha Martin,Ignacio Varela,Graham R. Bignell,Lucy R. Yates,Lucy R. Yates,Elli Papaemmanuil,David Beare,Adam Butler,Angela Cheverton,John Gamble,Jonathan Hinton,Mingming Jia,Alagu Jayakumar,David Jones,Calli Latimer,King Wai Lau,Stuart McLaren,David J. McBride,Andrew Menzies,L. Mudie,Keiran Raine,Roland Rad,Michael Spencer Chapman,Jon W. Teague,Douglas F. Easton,Anita Langerød,Ming Ta Michael Lee,Chen-Yang Shen,Benita Tan Kiat Tee,Bernice Wong Huimin,Annegien Broeks,Ana Cristina Vargas,Gulisa Turashvili,John W.M. Martens,Aquila Fatima,Penelope Miron,Suet-Feung Chin,Gilles Thomas,Sandrine Boyault,Odette Mariani,Sunil R. Lakhani,Sunil R. Lakhani,Marc J. van de Vijver,Laura van 't Veer,John A. Foekens,Christine Desmedt,Christos Sotiriou,Andrew Tutt,Carlos Caldas,Carlos Caldas,Jorge S. Reis-Filho,Samuel Aparicio,Anne Vincent Salomon,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,P. Andrew Futreal,Michael R. Stratton +69 more
TL;DR: Strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade are found, and multiple mutational signatures are observed, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides.
Journal ArticleDOI
Whole exome sequencing of adenoid cystic carcinoma
Philip J. Stephens,Helen Davies,Yoshitsugu Mitani,Peter Van Loo,Peter Van Loo,Adam Shlien,Patrick S. Tarpey,Elli Papaemmanuil,Angela Cheverton,Graham R. Bignell,Adam Butler,John Gamble,Stephen J. Gamble,Claire Hardy,Jonathan Hinton,Mingming Jia,Alagu Jayakumar,David T. Jones,Calli Latimer,Stuart McLaren,David J. McBride,Andrew Menzies,Laura Mudie,Mark Maddison,Keiran Raine,Serena Nik-Zainal,Sarah O’Meara,Jon W. Teague,Ignacio Varela,David C. Wedge,Ian Whitmore,Scott M. Lippman,Ultan McDermott,Michael R. Stratton,Peter J. Campbell,Adel K. El-Naggar,P. Andrew Futreal +36 more
TL;DR: Exome sequencing in a series of 24 ACC cases identified multiple mutated genes that, combined, implicate chromatin deregulation in half of cases and identified the negative NOTCH signaling regulator, SPEN, as a new cancer gene in ACC with mutations in 5 cases.