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Angela Mitri
Researcher at University of Toronto
Publications - 14
Citations - 1770
Angela Mitri is an academic researcher from University of Toronto. The author has contributed to research in topics: Germline mutation & Adenomatous polyposis coli. The author has an hindex of 12, co-authored 14 publications receiving 1733 citations. Previous affiliations of Angela Mitri include Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
Armin Reitmair,Rudolf Schmits,A. Ewel,Bharati Bapat,Mark Redston,Angela Mitri,Paul Waterhouse,Hans-Willi Mittrücker,Andrew Wakeham,B. Liu,A. Thomason,Henrik Griesser,Steve Gallinger,W.G. Ballhausen,Richard Fishel,T. W. Mak +15 more
TL;DR: A direct link between MSH2 deficiency and the pathogenesis of cancer is established and these mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti–cancer agents.
Journal ArticleDOI
Genotype-Phenotype Correlations in Attenuated Adenomatous Polyposis Coli
Claudio Soravia,Terri Berk,Lisa Madlensky,Angela Mitri,Hong Cheng,Steven Gallinger,Zane Cohen,Bharati Bapat +7 more
TL;DR: The data suggest that, in AAPC families, the location of the APC mutation may partially predict specific phenotypic expression, which should help in the design of tailored clinical-management protocols in this subset of FAP patients.
Journal Article
Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.
Andrew J. Smith,Hartley Stern,Mark Penner,Kazy Hay,Angela Mitri,Bharati Bapat,Steven Gallinger +6 more
TL;DR: The results of this study demonstrate that both APC and K-ras mutations occur in ACF, and support the role of the ACF as a colorectal cancer precursor and provide further insight into the early genetic changes which occur during coloreCTal tumorigenesis.
Journal Article
MSH2 Deficiency Contributes to Accelerated APC-mediated Intestinal Tumorigenesis
Armin Reitmair,Jian-Chun Cai,Matthew Bjerknes,Mark Redston,Hazel Cheng,Molly T. L. Pind,Kazy Hay,Angela Mitri,Bharati Bapat,Tak W. Mak,Steven Gallinger +10 more
TL;DR: Evidence is provided for the important role of MMR genes in accelerated intestinal tumorigenesis, thus supporting more aggressive surveillance strategies to prevent colorectal cancer in hereditary nonpolyposis coloreCTal cancer.
Journal ArticleDOI
Familial adenomatous polyposis-associated thyroid cancer: a clinical, pathological, and molecular genetics study
Claudio Soravia,Sonia L. Sugg,Terri Berk,Angela Mitri,Hong Cheng,Steven Gallinger,Zane Cohen,Sylvia L. Asa,Bharati Bapat +8 more
TL;DR: The data suggest that genetic alterations in FAP-associated thyroid cancer involve loss of function of APC along with the gain offunction of ret/PTC, while alterations of p53 do not appear to be an early event in thyroid tumorigenesis.