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Armin Reitmair
Researcher at Allergan
Publications - 21
Citations - 2263
Armin Reitmair is an academic researcher from Allergan. The author has contributed to research in topics: MSH2 & DNA mismatch repair. The author has an hindex of 16, co-authored 21 publications receiving 2193 citations. Previous affiliations of Armin Reitmair include French Institute of Health and Medical Research & University of Toronto.
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Journal ArticleDOI
The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
Razqallah Hakem,Razqallah Hakem,José Luis de la Pompa,José Luis de la Pompa,Christian Sirard,Christian Sirard,Rong Mo,Minna Woo,Minna Woo,Anne Hakem,Anne Hakem,Andrew Wakeham,Andrew Wakeham,Julia Potter,Julia Potter,Armin Reitmair,Armin Reitmair,Filio Billia,Eduardo Firpo,Chi-chung Hui,James M. Roberts,Janet Rossant,Janet Rossant,Tak W. Mak,Tak W. Mak +24 more
TL;DR: The death of Brca1(5-6) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers, and the fact that mutant blastocyst growth is grossly impaired in vitro.
Journal ArticleDOI
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
Armin Reitmair,Rudolf Schmits,A. Ewel,Bharati Bapat,Mark Redston,Angela Mitri,Paul Waterhouse,Hans-Willi Mittrücker,Andrew Wakeham,B. Liu,A. Thomason,Henrik Griesser,Steve Gallinger,W.G. Ballhausen,Richard Fishel,T. W. Mak +15 more
TL;DR: A direct link between MSH2 deficiency and the pathogenesis of cancer is established and these mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti–cancer agents.
Journal ArticleDOI
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL
Lucia Altucci,Lucia Altucci,Aurélie Rossin,Wolfgang Raffelsberger,Armin Reitmair,Christine Chomienne,Hinrich Gronemeyer +6 more
TL;DR: Induction of TRAIL-mediated death signaling appears to contribute to the therapeutic value of retinoids in the leukemic blasts of freshly diagnosed acute promyelocytic leukemia patients.
Journal Article
MSH2 Deficiency Contributes to Accelerated APC-mediated Intestinal Tumorigenesis
Armin Reitmair,Jian-Chun Cai,Matthew Bjerknes,Mark Redston,Hazel Cheng,Molly T. L. Pind,Kazy Hay,Angela Mitri,Bharati Bapat,Tak W. Mak,Steven Gallinger +10 more
TL;DR: Evidence is provided for the important role of MMR genes in accelerated intestinal tumorigenesis, thus supporting more aggressive surveillance strategies to prevent colorectal cancer in hereditary nonpolyposis coloreCTal cancer.
Journal Article
Spontaneous Intestinal Carcinomas and Skin Neoplasms in Msh2-deficient Mice
Armin Reitmair,Mark Redston,Jian Chun Cai,Tony C. Y. Chuang,Matthew Bjerknes,Hazel Cheng,Kazy Hay,Steven Gallinger,Bharati Bapat,Tak W. Mak +9 more
TL;DR: Tumor susceptibility of the recently described Msh2-deficient mouse model implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans.