R
Rudolf Schmits
Researcher at Ontario Institute for Cancer Research
Publications - 5
Citations - 793
Rudolf Schmits is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: T lymphocyte & Immune system. The author has an hindex of 4, co-authored 5 publications receiving 768 citations.
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Journal ArticleDOI
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
Armin Reitmair,Rudolf Schmits,A. Ewel,Bharati Bapat,Mark Redston,Angela Mitri,Paul Waterhouse,Hans-Willi Mittrücker,Andrew Wakeham,B. Liu,A. Thomason,Henrik Griesser,Steve Gallinger,W.G. Ballhausen,Richard Fishel,T. W. Mak +15 more
TL;DR: A direct link between MSH2 deficiency and the pathogenesis of cancer is established and these mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti–cancer agents.
Journal ArticleDOI
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.
Rudolf Schmits,Thomas M. Kündig,D. M. Baker,G. Shumaker,John J.L. Simard,Gordon S. Duncan,Andrew Wakeham,Arda Shahinian,A. Van Der Heiden,Martin F. Bachmann,Pamela S. Ohashi,Tak W. Mak,D. D. Hickstein +12 more
TL;DR: The leukocyte integrin LFA-1 (CD11a/CD18) deficiency causes a selective defect in induction of peripheral immune responses whereas responses to systemic infection are normal.
Journal ArticleDOI
Transendothelial migration and trafficking of leukocytes in LFA‐1‐deficient mice
David P. Andrew,Jason P. Spellberg,Hiroaki Takimoto,Rudolf Schmits,Tak W. Mak,Mark M. Zukowski +5 more
TL;DR: It is demonstrated that LFA‐1 regulates the trafficking of lymphocytes to peripheral lymph nodes, and, to a lesser degree, to mesenteric lymphnodes and acute inflammatory sites.
Journal ArticleDOI
T-lymphocyte development and function in gene-targeted mutant mice.
TL;DR: Recent results from the analysis of mice with targeted mutations of genes involved in the immune system are summarized, with the main focus on the regulation of T-lymphocyte development and activation in mutant mice generated in the authors' own and other laboratories.
Formation, and Tumorigenicity CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma
Pamela S. Ohashi,Christopher J. Paige,Jose C. Gutierrez-Ramos,Tak W. Mak,Andrew Wakeham,Arda Shahinian,Charles Catzavelos,Janusz Rak,Caren Furlonger,Arsen Zakarian,Rudolf Schmits,Jorge Filmus,Nicole Gerwin,Giorgio Senaldi,Friedemann Kiefer,Thomas M. Kündig +15 more