A
Al Ivens
Researcher at Wellcome Trust Sanger Institute
Publications - 38
Citations - 4003
Al Ivens is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 27, co-authored 38 publications receiving 3779 citations. Previous affiliations of Al Ivens include Wellcome Trust & University of Edinburgh.
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Journal ArticleDOI
The Genome of the African Trypanosome Trypanosoma brucei
Matthew Berriman,Elodie Ghedin,Elodie Ghedin,Christiane Hertz-Fowler,Gaëlle Blandin,Hubert Renauld,Daniella Castanheira Bartholomeu,Nicola Lennard,Elisabet Caler,N. Hamlin,Brian J. Haas,Ulrike Böhme,Linda Hannick,Martin Aslett,Joshua Shallom,Lucio Marcello,Lihua Hou,Bill Wickstead,U. Cecilia M. Alsmark,Claire Arrowsmith,Rebecca Atkin,Andrew Barron,Frédéric Bringaud,Karen Brooks,Mark Carrington,Inna Cherevach,Tracey-Jane Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Robert L. Davies,Jonathon Doggett,Appolinaire Djikeng,Tamara Feldblyum,Mark C. Field,Audrey Fraser,Ian Goodhead,Zahra Hance,David Harper,Barbara Harris,Heidi Hauser,Jessica B. Hostetler,Al Ivens,Kay Jagels,David W. Johnson,Justin Johnson,Kristine Jones,Arnaud Kerhornou,Hean Koo,Natasha Larke,Scott M. Landfear,Christopher Larkin,Vanessa Leech,Alexandra Line,Angela Lord,Annette MacLeod,P. Mooney,Sharon Moule,David M. A. Martin,Gareth W. Morgan,Karen Mungall,Halina Norbertczak,Doug Ormond,Grace Pai,Christopher S. Peacock,Jeremy Peterson,Michael A. Quail,Ester Rabbinowitsch,Marie-Adèle Rajandream,Chris P Reitter,Steven L. Salzberg,Mandy Sanders,Seth Schobel,Sarah Sharp,Mark Simmonds,Anjana J. Simpson,Luke J. Tallon,C. Michael R. Turner,Andrew Tait,Adrian Tivey,Susan Van Aken,Danielle Walker,David Wanless,Shiliang Wang,Brian White,Owen White,Sally Whitehead,John Woodward,Jennifer R. Wortman,Mark Raymond Adams,T. Martin Embley,Keith Gull,Elisabetta Ullu,J. David Barry,Alan H. Fairlamb,Fred R. Opperdoes,Barclay G. Barrell,John E. Donelson,Neil Hall,Neil Hall,Claire M. Fraser,Sara E. Melville,Najib M. El-Sayed,Najib M. El-Sayed +104 more
TL;DR: Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Journal ArticleDOI
The genome of the simian and human malaria parasite Plasmodium knowlesi
Arnab Pain,Ulrike Böhme,Andrew Berry,Karen Mungall,Robert D. Finn,Andrew P. Jackson,Tobias Mourier,Jaina Mistry,Erica M. Pasini,Martin Aslett,S. Balasubrammaniam,Karsten M. Borgwardt,Karen Brooks,Celine Carret,Tim Carver,Inna Cherevach,Tracey Chillingworth,Taane G. Clark,Taane G. Clark,Mary R. Galinski,Neil Hall,D. Harper,David Harris,Heidi Hauser,Al Ivens,Christoph S. Janssen,Thomas M. Keane,Natasha Larke,Stacey A. Lapp,Matthias Marti,Sharon Moule,Irmtraud M. Meyer,Douglas Ormond,Nicholas S. Peters,Mandy Sanders,S. Sanders,Tobias Sargeant,Tobias Sargeant,Mark Simmonds,Frances Smith,R. Squares,Scott Thurston,Adrian Tivey,Danielle Walker,Brian White,Eduard Zuiderwijk,Carol Churcher,Michael A. Quail,Alan F. Cowman,C. M. R. Turner,Marie-Adèle Rajandream,Clemens H. M. Kocken,Alan W. Thomas,Chris I. Newbold,Chris I. Newbold,Bart Barrell,Matthew Berriman +56 more
TL;DR: This is the first monkey malaria parasite genome to be described, and it provides an opportunity for comparison with the recently completed P. vivax genome and other sequenced Plasmodium genomes.
Journal ArticleDOI
An H-NS-like stealth protein aids horizontal DNA transmission in bacteria.
TL;DR: It is found that Sfh provides a stealth function that allows the plasmids to be transmitted to new bacterial hosts with minimal effects on their fitness, and has important implications for bacterial evolution.
Journal ArticleDOI
Genome-wide expression profiling of in vivo- derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei
Sarah Kabani,Katelyn Fenn,Alan J. Ross,Al Ivens,Terry K. Smith,Peter Ghazal,Keith R. Matthews +6 more
TL;DR: The profile of regulated gene expression during these important life-cycle transitions of trypanosome differentiation is established using stringent statistical analysis and validation of the derived profiles against experimentally-predicted gene expression and phenotypic changes.
Journal ArticleDOI
The Global Consequence of Disruption of the AcrAB-TolC Efflux Pump in Salmonella enterica Includes Reduced Expression of SPI-1 and Other Attributes Required To Infect the Host
Mark A. Webber,Andrew M. Bailey,Jessica M A Blair,Eirwen Morgan,Mark P. Stevens,Jay C. D. Hinton,Al Ivens,John Wain,Laura J. V. Piddock +8 more
TL;DR: It is demonstrated that AcrA, AcrB, and TolC are each required for efficient adhesion to and invasion of epithelial cells and macrophages by Salmonella in vitro.