Anissa Viveiros

TL;DR: A review summarizes the progress over the past 20 years, highlighting the critical role of ACE2 as the novel SARS-CoV-2 receptor and as the negative regulator of the renin-angiotensin system, together with implications for the coronavirus disease 2019 pandemic and associated cardiovascular diseases.

TL;DR: The state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease and provides a valuable reference for future studies.

TL;DR: Potential mechanisms involved in COVID-19 that may contribute to sex-specific susceptibility focusing on the innate immune system and the RAS, namely, genetics and sex hormones are explored.

TL;DR: Using single-nucleus RNA sequencing, the transcriptome of 880,000 nuclei from 18 control and 61 failing, nonischemic human hearts is characterized, illuminating both shared and distinct cellular and molecular architectures of human heart failure and suggest candidate therapeutic targets.

TL;DR: The rationale for pharmacological targeting of the perivascular and epicardial adipose tissue or associated signaling pathways as potential disease modifying approaches in cardiometabolic syndromes is highlighted.