L
Leanne E. Felkin
Researcher at National Institutes of Health
Publications - 55
Citations - 2972
Leanne E. Felkin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heart failure & Transplantation. The author has an hindex of 25, co-authored 54 publications receiving 2356 citations. Previous affiliations of Leanne E. Felkin include Royal Brompton & Harefield NHS Foundation Trust & Imperial College London.
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Journal ArticleDOI
The Translational Landscape of the Human Heart
Sebastiaan van Heesch,Franziska Witte,Valentin Schneider-Lunitz,Jana Felicitas Schulz,Eleonora Adami,Eleonora Adami,Allison Faber,Marieluise Kirchner,Henrike Maatz,Susanne Blachut,Clara-Louisa Sandmann,Masatoshi Kanda,Catherine L. Worth,Sebastian Schafer,Sebastian Schafer,Lorenzo Calviello,Lorenzo Calviello,Rhys Merriott,Giannino Patone,Oliver Hummel,Emanuel Wyler,Benedikt Obermayer,Michael Benedikt Mucke,Eric L. Lindberg,Franziska Trnka,Sebastian Memczak,Marcel Schilling,Leanne E. Felkin,Paul J.R. Barton,Nicholas M Quaife,Nicholas M Quaife,Konstantinos Vanezis,Konstantinos Vanezis,Sebastian Diecke,Sebastian Diecke,Masaya Mukai,Nancy Mah,Su-Jun Oh,Andreas Kurtz,Christoph Schramm,Dorothee Schwinge,Marcial Sebode,Magdalena Harakalova,Folkert W. Asselbergs,Folkert W. Asselbergs,Aryan Vink,Roel A. de Weger,Sivakumar Viswanathan,Anissa A. Widjaja,Anna Gärtner-Rommel,Hendrik Milting,Cris dos Remedios,Christoph Knosalla,Christoph Knosalla,Philipp Mertins,Markus Landthaler,Markus Landthaler,Martin Vingron,Wolfgang A. Linke,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Nikolaus Rajewsky,Uwe Ohler,Uwe Ohler,Stuart A. Cook,Norbert Hubner +67 more
TL;DR: This work analyzes the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation, and shows extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner.
Journal ArticleDOI
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Angharad M. Roberts,Angharad M. Roberts,James S. Ware,Daniel S. Herman,Daniel S. Herman,Daniel S. Herman,Sebastian Schafer,John Baksi,Alexander G. Bick,Alexander G. Bick,Rachel Buchan,Roddy Walsh,Shibu John,S Wilkinson,Francesco Mazzarotto,Francesco Mazzarotto,Leanne E. Felkin,Leanne E. Felkin,Sungsam Gong,Jacqueline A. L. MacArthur,Fiona Cunningham,Jason Flannick,Jason Flannick,Stacey Gabriel,David Altshuler,David Altshuler,Peter S. Macdonald,Peter S. Macdonald,Peter S. Macdonald,Matthias Heinig,Anne Keogh,Anne Keogh,Anne Keogh,Christopher S. Hayward,Christopher S. Hayward,Christopher S. Hayward,Nicholas R. Banner,Nicholas R. Banner,Dudley J. Pennell,Dudley J. Pennell,Declan P. O'Regan,Tan Ru San,Antonio de Marvao,Timothy J W Dawes,Ankur Gulati,Emma J. Birks,Emma J. Birks,Magdi H. Yacoub,Michael H. Radke,Michael Gotthardt,James G. Wilson,Christopher J. O'Donnell,Sanjay K Prasad,Paul J.R. Barton,Paul J.R. Barton,Diane Fatkin,Diane Fatkin,Diane Fatkin,Norbert Hubner,Norbert Hubner,Jonathan G. Seidman,Christine E. Seidman,Stuart A. Cook +62 more
TL;DR: It is shown that TTNtv is the most common genetic cause of DCM in ambulant patients in the community, identify clinically important manifestations ofTTNtv-positive DCM, and define the penetrance and outcomes of TTNTV in the general population.
Journal ArticleDOI
Direct Intramyocardial But Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model
Satsuki Fukushima,Anabel Varela-Carver,Steven R. Coppen,Kenichi Yamahara,Leanne E. Felkin,Joon Ha Lee,Paul J.R. Barton,Cesare M. Terracciano,Magdi H. Yacoub,Ken Suzuki +9 more
TL;DR: BM cell injection is able to improve cardiac function in ischemic chronic heart failure but has a risk of arrhythmia occurrence when the intramyocardial route is used and such arrhythmias may be prevented by using the intracoronary route.
Journal ArticleDOI
Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes
Roddy Walsh,Roddy Walsh,Rachel Buchan,Rachel Buchan,Alicja Wilk,Alicja Wilk,Shibu John,Shibu John,Leanne E. Felkin,Leanne E. Felkin,K Thomson,K Thomson,Tang Hak Chiaw,Calvin Chin Woon Loong,Chee Jian Pua,Claire E. Raphael,Sanjay K Prasad,Paul J.R. Barton,Paul J.R. Barton,Birgit Funke,Birgit Funke,Hugh Watkins,Hugh Watkins,James S. Ware,James S. Ware,Stuart A. Cook +25 more
TL;DR: It is shown that genetic variation in the majority of non-sarcomeric genes implicated in HCM is not associated with the condition, reinforce the fact that the sarcomeric gene variation is the primary cause of HCM known to date and underscore that the aetiology of H CM is unknown in themajority of patients.
Journal ArticleDOI
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
Chris McDermott-Roe,Junmei Ye,Rizwan Ahmed,Xi-Ming Sun,Anna Serafín,James S. Ware,Leonardo Bottolo,Phil Muckett,Xavier Cañas,Jisheng Zhang,Glenn C. Rowe,Rachel Buchan,Han Lu,Adam Braithwaite,Massimiliano Mancini,David Hauton,Ramon Martí,Elena García-Arumí,Norbert Hubner,Norbert Hubner,Howard J. Jacob,Tadao Serikawa,Vaclav Zidek,Frantisek Papousek,Frantisek Kolar,Maria Cardona,Marisol Ruiz-Meana,David Garcia-Dorado,Joan X. Comella,Leanne E. Felkin,Paul J.R. Barton,Zoltan Arany,Michal Pravenec,Enrico Petretto,Daniel Sanchis,Stuart A. Cook +35 more
TL;DR: This study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy.