Anja Leona Biere

TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.

TL;DR: It is shown that both wild type and mutant α-synuclein form insoluble fibrillar aggregates with antiparallel β-sheet structure upon incubation at physiological temperature in vitro, and that aggregate formation is accelerated by both PD-linked mutations.

TL;DR: It is suggested that differences in aggregation kinetics of alpha-synucleins cannot be explained by differences in solubility but are due to different nucleation rates, and alpha- Synuclein nucleation may be the rate-limiting step for the formation of Lewy body alpha- synuclein fibrils in Parkinson's disease.

TL;DR: Data show that chronic NSAID treatment can reduce brain Aβ levels, amyloid plaque burden, and microglial activation in an animal model of Alzheimer's disease.

TL;DR: β- and γ-synuclein are intrinsically less fibrillogenic than α- Synuclein and cannot form mixed fibrils with α- synuclein, which may explain why they do not appear in the pathological hallmarks of PD, although they are closely related to α-syn nuclein and are also abundant in brain.