Ann M. Rasmusson

TL;DR: This Review attempts to present the current state of understanding of post-traumatic stress disorder on the basis of psychophysiological, structural and functional neuroimaging, and endocrinological, genetic and molecular biological studies in humans and in animal models.

TL;DR: The normalization of CSF ALLO content in depressed patients appears to be sufficient to mediate the anxiolytic and antidysphoric actions of fluoxetine or fluvoxamine via its positive allosteric modulation of GABA type A receptors.

TL;DR: This review focuses on the role of norepinephrine in traumatic stress by focusing on a series of yohimbine studies in subjects with PTSD because data from these studies allow for a discussion that brings together preclinical and clinical findings relevant to trauma-related alterations in arousal and memory.

TL;DR: Evidence is provided of amygdalar control of stress-induced metabolic activation of the monoaminergic systems in the m-PFC, as well as amygdAlar integration of behavioral and neuroendocrine components of the rat stress response.

TL;DR: The DHEA-S-cortisol ratios during stress were significantly higher in subjects who reported fewer symptoms of dissociation and exhibited superior military performance, providing prospective, empirical evidence that the DHEa-S level is increased by acute stress in healthy humans and that the Cortisol ratio may index the degree to which an individual is buffered against the negative effects of stress.