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Anna C. Need
Researcher at Imperial College London
Publications - 92
Citations - 11954
Anna C. Need is an academic researcher from Imperial College London. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 43, co-authored 73 publications receiving 10623 citations. Previous affiliations of Anna C. Need include Queen Mary University of London & University College London.
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Journal ArticleDOI
Exome sequence analysis of Finnish patients with clozapine-induced agranulocytosis
Arun K. Tiwari,Anna C. Need,Falk W. Lohoff,Clement C. Zai,Nabilah I. Chowdhury,Daniel J. Müller,Anu Putkonen,Eila Repo-Tiihonen,Tero Hallikainen,A.E. Anıl Yağcıoğlu,Jari Tiihonen,Jari Tiihonen,J.L. Kennedy,Herbert Y. Meltzer +13 more
TL;DR: The association of CNR1 variants with psychotomimetic effects induced by cannabis at first use could accurately reflect the genetic risk of psychosis when exposed to cannabis, by avoiding the confounding factors of preexisting psychosis or the association of these genetic variants to psychosis or addiction.
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Learning and memory impairments in Kv beta 1.1-null mutants are rescued by environmental enrichment or ageing.
TL;DR: It is found that performance in the STFP task is age‐dependent and involves the hippocampus, and it is suggested that the loss of Kvβ1.1 function is beneficial for L’& M in middle age.
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Genetic enhancement of cognition in a kindred with cone–rod dystrophy due to RIMS1 mutation
Sanjay M. Sisodiya,Pamela J. Thompson,Anna C. Need,Sarah E. Harris,Michael E. Weale,Susan E. Wilkie,Michel Michaelides,Samantha L. Free,Nicole M. Walley,Curtis Gumbs,Dianne Gerrelli,Piers Ruddle,Lawrence J. Whalley,John M. Starr,David M. Hunt,David Goldstein,Ian J. Deary,Anthony T. Moore +17 more
TL;DR: The findings suggest that genetic mutation may enhance human cognition in some cases and a possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested.
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The RBMX gene as a candidate for the Shashi X-linked intellectual disability syndrome.
Vandana Shashi,Pingxing Xie,Kelly Schoch,David Goldstein,Timothy D. Howard,Margaret N. Berry,C.E. Schwartz,Kenneth D. Cronin,S. Sliwa,Andrew S. Allen,Anna C. Need +10 more
TL;DR: A 23 bp frameshift deletion in the RNA binding motif protein X‐linked (RBMX) gene is identified in the affected males, one carrier female, absent in unaffected males and in control databases and may enable the identification of other individuals affected with this distinctive syndrome.
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Genome-wide tagging for everyone
Anna C. Need,David Goldstein +1 more
TL;DR: Two new studies show that the patterns of variation documented in the HapMap can be applied to other human populations, suggesting it is time to establish a standardized platform for all whole-genome association studies.