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Anna C. Need
Researcher at Imperial College London
Publications - 92
Citations - 11954
Anna C. Need is an academic researcher from Imperial College London. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 43, co-authored 73 publications receiving 10623 citations. Previous affiliations of Anna C. Need include Queen Mary University of London & University College London.
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Journal ArticleDOI
Copy number variation of KIR genes influences HIV-1 control.
Kimberly Pelak,Anna C. Need,Jacques Fellay,Jacques Fellay,Kevin V. Shianna,Sheng Feng,Thomas J. Urban,Dongliang Ge,Andrea De Luca,Andrea De Luca,Javier Martinez-Picado,Steven M. Wolinsky,Jeremy J. Martinson,Beth D. Jamieson,Jay H. Bream,Maureen P. Martin,Persephone Borrow,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Amalio Telenti,Mary Carrington,Mary Carrington,David Goldstein,Galit Alter,Aids Vaccine Immunology +25 more
TL;DR: The authors that the number of activating and inhibitory KIR genes varies between individuals and plays a role in the regulation of immune mechanisms that determine HIV-1 control.
Journal ArticleDOI
Using ERDS to Infer Copy-Number Variants in High-Coverage Genomes
Mingfu Zhu,Anna C. Need,Yujun Han,Dongliang Ge,Jessica M. Maia,Qianqian Zhu,Erin L. Heinzen,Elizabeth T. Cirulli,Kimberly Pelak,Min He,Elizabeth K. Ruzzo,Curtis Gumbs,Abanish Singh,Sheng Feng,Kevin V. Shianna,David Goldstein +15 more
TL;DR: Comparisons show that for genomes sequenced at high coverage, ERDS provides a computationally convenient method that calls CNVs as well as or better than any currently available method.
Journal ArticleDOI
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
Anna C. Need,Deborah K. Attix,Jill M. McEvoy,Elizabeth T. Cirulli,Kristen L. Linney,Priscilla Hunt,Dongliang Ge,Erin L. Heinzen,Jessica M. Maia,Kevin V. Shianna,Michael E. Weale,Lynn Cherkas,Gail Clement,Tim D. Spector,Greg Gibson,David Goldstein +15 more
TL;DR: The results suggest that common genetic variation does not strongly influence cognition in healthy subjects and that cognitive measures do not represent a more tractable genetic trait than clinical endpoints such as schizophrenia.
Journal ArticleDOI
Priorities and standards in pharmacogenetic research.
TL;DR: As the attention of researchers begins to shift toward more systematic pharmacogenetic investigations, it is suggested some priorities and standards for pharmacogenetics research.
Journal ArticleDOI
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
Erin L. Heinzen,Anna C. Need,Kathleen M. Hayden,Ornit Chiba-Falek,Allen D. Roses,Warren J. Strittmatter,Burke,Christine M. Hulette,Kathleen A. Welsh-Bohmer,David Goldstein +9 more
TL;DR: A genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls is reported, extending analyses for the first time to include assessments of copy number variation and a duplication in CHRNA7 appears interesting enough to warrant further investigation.