A
Anna C. Need
Researcher at Imperial College London
Publications - 92
Citations - 11954
Anna C. Need is an academic researcher from Imperial College London. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 43, co-authored 73 publications receiving 10623 citations. Previous affiliations of Anna C. Need include Queen Mary University of London & University College London.
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Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets
Max Lam,Joey W. Trampush,Jin Yu,Emma Knowles,Gail Davies,David C. Liewald,John M. Starr,Srdjan Djurovic,Ingrid Melle,Kjetil Sundet,Andrea Christoforou,Ivar Reinvang,Pamela DeRosse,Astri J. Lundervold,Vidar M. Steen,Thomas Espeseth,Katri Räikkönen,Elisabeth Widen,Aarno Palotie,Johan G. Eriksson,Ina Giegling,Bettina Konte,Panos Roussos,Stella Giakoumaki,Katherine E. Burdick,Antony Payton,William Ollier,Ornit Chiba-Falek,Deborah K. Attix,Anna C. Need,Elizabeth T. Cirulli,Aristotle N. Voineskos,Nikos C. Stefanis,Dimitrios Avramopoulos,Alex Hatzimanolis,Dan E. Arking,Nikolaos Smyrnis,Robert M. Bilder,Nelson A. Freimer,Tyrone D. Cannon,Edythe D. London,Russell A. Poldrack,Fred W. Sabb,Eliza Congdon,Emily Drabant Conley,Matthew A. Scult,Dwight Dickinson,Richard E. Straub,Gary Donohoe,Derek W. Morris,Aiden Corvin,Michael Gill,Ahmad R. Hariri,Daniel R. Weinberger,Neil Pendleton,Panos Bitsios,Dan Rujescu,Jari Lahti,Stephanie Le Hellard,Stephanie Le Hellard,Matthew C. Keller,Ole A. Andreassen,Ian J. Deary,David C. Glahn,Anil K. Malhotra,Todd Lencz +65 more
TL;DR: The largest genome-wide association studies (GWAS) of cognitive ability to date are presented, and signal is enhanced by combining results with a large-scale GWAS of educational attainment.
Journal ArticleDOI
Correction: A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia
Anna C. Need,Dongliang Ge,Michael E. Weale,Jessica M. Maia,Sheng Feng,Erin L. Heinzen,Kevin V. Shianna,Woohyun Yoon,Dalia Kasperavičiūtė,Massimo Gennarelli,Warren J. Strittmatter,Cristian Bonvicini,Giuseppe Rossi,Karu Jayathilake,Philip A. Cola,Joseph P. McEvoy,Richard S.E. Keefe,Elizabeth M. C. Fisher,Pamela L. St. Jean,Ina Giegling,Annette M. Hartmann,Hans-Jürgen Möller,Andreas Ruppert,Gillian Fraser,Caroline Crombie,Lefkos T. Middleton,David St Clair,Allen D. Roses,Pierandrea Muglia,Clyde Francks,Dan Rujescu,Herbert Y. Meltzer,David Goldstein +32 more
TL;DR: The authors declare the following competing interest: Pamela L. St. Jean, Pierandrea Muglia, and Clyde Francks are full-time employees of GlaxoSmithKline, a pharmaceutical company that has filed patent applications for SNPs related to schizophrenia.
Posted ContentDOI
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies,Max Lam,Sarah E. Harris,Joey W. Trampush,Michelle Luciano,W. David Hill,Saskia P. Hagenaars,Stuart J. Ritchie,Riccardo E. Marioni,Chloe Fawns-Ritchie,David C. Liewald,Judith A. Okely,Ari Ahola-Olli,Catriona L. K. Barnes,Lars Bertram,Joshua C. Bis,Katherine E. Burdick,Andrea Christoforou,Pamela DeRosse,Srdjan Djurovic,Thomas Espeseth,Stella G. Giakoumaki,Sudheer Giddaluru,Daniel E. Gustavson,Caroline Hayward,Edith Hofer,M. Arfan Ikram,Robert Karlsson,Emma Knowles,Jari Lahti,Markus Leber,Shuo Li,Karen A. Mather,Ingrid Melle,Derek W. Morris,Christopher Oldmeadow,Teemu Palviainen,Antony Payton,Raha Pazoki,Katja Petrovic,Chandra A. Reynolds,Muralidharan Sargurupremraj,Markus Scholz,Jennifer A. Smith,Albert V. Smith,Natalie Terzikhan,Anbupalam Thalamuthu,Stella Trompet,Sven J. van der Lee,Erin B. Ware,Beverly Gwen Windham,Margaret J. Wright,Jingyun Yang,Jin Yu,David Ames,Najaf Amin,Philippe Amouyel,Ole A. Andreassen,Nicola J. Armstrong,Amelia A. Assareh,John Attia,Deborah K. Attix,Dimitrios Avramopoulos,David A. Bennett,Anne C. Böhmer,Patricia A. Boyle,Henry Brodaty,Harry Campbell,Tyrone D. Cannon,Elizabeth T. Cirulli,Eliza Congdon,Emily Drabant Conley,Janie Corley,Simon R. Cox,Anders M. Dale,Abbas Dehghan,Danielle M. Dick,Dwight Dickinson,Johan G. Eriksson,Evangelos Evangelou,Jessica D. Faul,Ian Ford,Nelson A. Freimer,He Gao,Ina Giegling,Nathan A. Gillespie,Scott D. Gordon,R. F. Gottesman,Michael Griswold,Vilmundur Gudnason,Tamara B. Harris,Annette M. Hartmann,Alex Hatzimanolis,Gerardo Heiss,Elizabeth G. Holliday,Peter K. Joshi,Mika Kähönen,Sharon L.R. Kardia,Ida K. Karlsson,Luca Kleineidam,David S. Knopman,Nicole A. Kochan,Bettina Konte,John B.J. Kwok,Stephanie Le Hellard,Teresa Lee,Terho Lehtimäki,Shu-Chen Li,Tian Liu,Marisa Koini,Edythe D. London,Will Longstreth,Oscar L. Lopez,Anu Loukola,Tobias Luck,Astri J. Lundervold,Anders Lundquist,Leo-Pekka Lyytikäinen,Nicholas G. Martin,Grant W. Montgomery,Alison D. Murray,Anna C. Need,Raymond Noordam,Lars Nyberg,William Ollier,Goran Papenberg,Alison Pattie,Ozren Polasek,Russell A. Poldrack,Bruce M. Psaty,Simone Reppermund,Steffi G. Riedel-Heller,Richard J. Rose,Jerome I. Rotter,Panos Roussos,Suvi P. Rovio,Yasaman Saba,Fred W. Sabb,Perminder S. Sachdev,Claudia L. Satizabal,Matthias Schmid,Rodney J. Scott,Matthew A. Scult,Jeannette Simino,P. Eline Slagboom,Nikolaos Smyrnis,Aicha Soumare,Nikos C. Stefanis,David J. Stott,Richard E. Straub,Kjetil Sundet,Adele M. Taylor,Kent D. Taylor,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Veronique Vitart,Aristotle N. Voineskos,Eero Vuoksimaa,Michael Wagner,Holger Wagner,Leonie Weinhold,K. Hoyan Wen,Elisabeth Widen,Qiong Yang,Wei Zhao,Hieab H.H. Adams,Dan E. Arking,Robert M. Bilder,Panos Bitsios,Eric Boerwinkle,Ornit Chiba-Falek,Aiden Corvin,Philip L. De Jager,Stéphanie Debette,Gary Donohoe,Paul Elliott,Annette L. Fitzpatrick,Michael Gill,David C. Glahn,Sara Hägg,Narelle K. Hansell,Ahmad R. Hariri,M. Kamran Ikram,J. Wouter Jukema,Jaakko Kaprio,Matthew C. Keller,William S. Kremen,Lenore J. Launer,Ulman Lindenberger,Aarno Palotie,Nancy L. Pedersen,Neil Pendleton,David J. Porteous,Katri Räikkönen,Olli T. Raitakari,Alfredo Ramirez,Ivar Reinvang,Igor Rudan,Dan Rujescu,Reinhold Schmidt,Helena Schmidt,Peter W. Schofield,Peter R. Schofield,John M. Starr,Vidar M. Steen,Julian N. Trollor,Steven T. Turner,Cornelia M. van Duijn,Arno Villringer,Daniel R. Weinberger,David R. Weir,James F. Wilson,Anil K. Malhotra,Anil K. Malhotra,Andrew M. McIntosh,Catharine R. Gale,Sudha Seshadri,Thomas H. Mosley,Jan Bressler,Todd Lencz,Ian J. Deary +221 more
TL;DR: Cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank were combined to find 9,714 genome-wide significant SNPs, with significant genetic overlap between general cognitive function and information processing speed, as well as many health variables including longevity.
Journal ArticleDOI
Publisher Correction: Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy
Nadine Spielmann,Gregor Miller,Tudor I. Oprea,Chih-Wei Hsu,Gisela Fobo,Goar Frishman,Corinna Montrone,Hamed Haseli Mashhadi,Jeremy Mason,Violeta Munoz Fuentes,Stefanie Leuchtenberger,Andreas Ruepp,Matias Wagner,Dominik S. Westphal,Cordula M. Wolf,Agnes Görlach,Adrian Sanz-Moreno,Yi-Li Cho,Raffaele Teperino,Stefan Brandmaier,Sapna Sharma,Isabella Galter,Manuela A. Östereicher,Lilly Zapf,Philipp Mayer-Kuckuk,Jan Rozman,Lydia Teboul,Rosie K. A. Bunton-Stasyshyn,Heather Cater,Michelle Stewart,Skevoulla Christou,Henrik Westerberg,Amelia M Willett,Janine M. Wotton,W. Roper,Audrey E. Christiansen,Christopher S. Ward,Jason D. Heaney,Corey L. Reynolds,Jan Prochazka,Lynette Bower,Dave Clary,Mohammed Selloum,Ghina Bou About,Olivia Wendling,Hugues Lortat Jacobs,Sophie Leblanc,Hamid Meziane,Tania Sorg,Enrique Audain,Arthur Gilly,Nigel W. Rayner,Juan Antonio Aguilar-Pimentel,Lore Becker,Lillian Garrett,Sabine M. Hölter,Oana V. Amarie,Julia Calzada-Wack,Tanja Klein-Rodewald,Patricia Da Silva-Buttkus,Christoph Lengger,Claudia Stoeger,Raffaele Gerlini,Birgit Rathkolb,D. Mayr,John R. Seavitt,Angelina Gaspero,Jennie R. Green,Arturo Garza,Ritu Bohat,Leeyean Wong,Melissa L. McElwee,Sowmya Kalaga,Tara L. Rasmussen,Isabel Lorenzo,Denise G. Lanza,Rodney C. Samaco,Surabi Veeraragaven,Juan Gallegos,Petr Kasparek,Silvia Petrezsélyová,Ruairidh King,Sara Johnson,James Cleak,Zsombor Szkoe-Kovacs,Gemma F. Codner,M Mackenzie,Adam Caulder,Janet Kenyon,Wendy J.K. Gardiner,Hayley Phelps,R.G.V. Hancock,Claire J. Norris,Michayla A Moore,Audrie M. Seluke,Rachel Urban,Coleen Kane,Leslie O. Goodwin,Kevin A. Peterson,Matthew Mckay,Jenn J. Cook,Jacob P. Lowy,Michael McFarland,Joshua A. Wood,Brandon J. Willis,H.A. Tolentino,Todd Tolentino,Michael A. Schuchbauer,Jason Eric Salazar,Jennifer M. Johnson,Rebecca Munson,Abdel Ayadi,Guillaume Pavlovic,Marie-Christine Birling,Sylvie Jacquot,Dalila Ali-Hadji,Philippe Charles,Philippe André,Marie-France Champy,Fabrice Riet,Igor Vukobradovic,Zorana Berberovic,Dawei Qu,Ruolin Guo,Abigail J. D’Souza,Ziyue Huang,Susan Camilleri,M Ganguly,Hibret A. Adissu,Mohammed R. Eskandarian,Xueyuan Shang,Kyle Duffin,Catherine Xu,Kyle Roberton,Valerie Laurin,Qing Lan,Gillian T. Sleep,Amie Creighton,Lauri G. Lintott,Marina Gertsenstein,Monica Pereira,Sandra Tondat,Amit N. Patel,Maribelle Cruz,Alexandr Bezginov,David Miller,Wang Hy,Atsushi Yoshiki,Nobuhiko Tanaka,Masaru Tamura,Zhiwei Liu,Olga Ermakova,Anna Ferrara,Paolo Fruscoloni,Claudia Seisenberger,Antje Bürger,Florian Giesert,J. Ambrose,P. Arumu gam,Roel P. J. Bevers,Marta Bleda,Freya Boardman-Pretty,Chris Boustred,Helen Brittain,Mark J. Caulfield,G. Chan,Tom Fowler,Adam Giess,A Hamblin,Seth Henderson,Tim Hubbard,R. Jackson,L. J. Jones,Dalia Kasperaviciute,Melis Kayikci,Athanasios Kousathanas,L. Lahnstein,Sarah Leigh,I. Leong,F. J. López,Fiona Maleady-Crowe,Meriel McEntagart,Fabiana Minneci,Loukas Moutsianas,M. Mueller,Nirupa Murugaesu,Anna C. Need,Peter O'Donovan,Christopher A. Odhams,Clyde L. Patch,Daniel Perez-Gil,M. Pereira,John Pullinger,T. Rahim,Augusto Rendon,Tim Rogers,K Savage,K. Sawant,Richard T. Scott,Afshan Siddiq,A. Sieghart,S.C. Smith,Alona Sosinsky,Alexander Stuckey,Mélanie Tanguy,A. L. Taylor-Tavares,Era Thomas,Simon G. Thompson,Arianna Tucci,M. Welland,Eleanor Williams,K. Witkowska,S. Wood,Marc-Phillip Hitz,Eleftheria Zeggini,Eckhard Wolf,Radislav Sedlacek,Stephen A. Murray,Karen L. Svenson,Robert Braun,J. K. White,Lois Kelsey,Xiang Gao,Toshihiko Shiroishi,Ying Xu,Je Kyung Seong,Fabio Mammano,Glauco P. Tocchini-Valentini,Arthur L. Beaudet,Terrence F. Meehan,Helen Parkinson,Damian Smedley,Ann-Marie Mallon,Sara Wells,Harald Grallert,Wolfgang Wurst,Susan Marschall,Helmut Fuchs,Steve D.M. Brown,Ann M. Flenniken,Lauryl M. J. Nutter,Colin McKerlie,Yann Herault,Kck Lloyd,Mary E. Dickinson,Valerie Gailus-Durner,Martin Hrabé de Angelis +246 more
TL;DR: In this paper , the authors used in vivo electrocardiography, transthoracic echocardiography and microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural and functional cardiac abnormalities, identifying 705 lines with cardiac arrhythmia, myocardial hypertrophy and ventricular dilation.
SVA: software for annotating and visualizing sequenced human
Elizabeth K. Ruzzo,Kevin V. Shianna,Min He,Kimberly Pelak,Erin L. Heinzen,Anna C. Need,Elizabeth T. Cirulli,Jessica M. Maia,Samuel P. Dickson,Mingfu Zhu,Abanish Singh,Andrew S. Allen,David Goldstein +12 more
TL;DR: Sequence Variant Analyzer (SVA) as mentioned in this paper is a software tool that assigns a predicted biological function to variants identified in next-generation sequencing studies and provides a browser to visualize the variants in their genomic contexts.