A
Anna Spada
Researcher at University of Milan
Publications - 326
Citations - 13577
Anna Spada is an academic researcher from University of Milan. The author has contributed to research in topics: Pituitary tumors & Acromegaly. The author has an hindex of 60, co-authored 322 publications receiving 12683 citations. Previous affiliations of Anna Spada include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
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Journal ArticleDOI
Genesis of pituitary adenomas: state of the art.
Giovanni Faglia,Anna Spada +1 more
TL;DR: Estrogen-inducible gene sequences with transforming properties (pituitary tumor-transforming gene (PTTG)) have been identified in human pituitary tumors and a role of cyclin D1 in pituitsary tumorigenesis is emerging.
Journal ArticleDOI
The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways
Erika Peverelli,Luca Olgiati,Marco Locatelli,Paolo Magni,Marco Faustini Fustini,Giorgio Frank,Giovanna Mantovani,Paolo Beck-Peccoz,Anna Spada,Andrea Lania +9 more
TL;DR: The chimeric compound BIM-23A760 is able to exert cytostatic and cytotoxic effects in NFPTs, these phenomena being mainly mediated by DR2D and involving ERK1/2 and p38 pathways activation.
Journal ArticleDOI
cAMP in the pituitary: an old messenger for multiple signals.
TL;DR: This review will discuss the central role of cAMP signaling in the pituitaries, focusing on the cAMP pathway alterations involved in pituitary tumorigenesis, as well as on poorly investigated aspects of camp cascade, such as crosstalk with the ERK signaling pathway and new cAMP effectors.
Journal ArticleDOI
Quantitative Analysis of Methylation Defects and Correlation With Clinical Characteristics in Patients With Pseudohypoparathyroidism Type I and GNAS Epigenetic Alterations
Francesca Elli,Luisa de Sanctis,Valentina Bollati,Letizia Tarantini,Marcello Filopanti,Anna Maria Barbieri,Erika Peverelli,Paolo Beck-Peccoz,Anna Spada,Giovanna Mantovani +9 more
TL;DR: Similar molecular alterations may lead to a broad spectrum of diseases, from isolated PTH resistance to complete PHP-Ia, and the degree of methylation alterations does not reflect or anticipate the severity and the type of different PHP/AHO manifestations.
Journal ArticleDOI
Different effects of short- and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults.
Claudia Giavoli,Vincenzo Cappiello,Sabrina Corbetta,Cristina L. Ronchi,P. S. Morpurgo,Emanuele Ferrante,Paolo Beck-Peccoz,Anna Spada +7 more
TL;DR: Evaluating circulating levels of ghrelin and adiponectin in GH‐deficient adults before and after short‐ and long‐term recombinant human GH (rhGH) administration finds no significant difference between the levels after short and long-term administration.