A
Anna Spada
Researcher at University of Milan
Publications - 326
Citations - 13577
Anna Spada is an academic researcher from University of Milan. The author has contributed to research in topics: Pituitary tumors & Acromegaly. The author has an hindex of 60, co-authored 322 publications receiving 12683 citations. Previous affiliations of Anna Spada include Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.
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Journal ArticleDOI
Growth factors and human pituitary adenomas
TL;DR: Several lines of evidence indicate that in pituitary tumors growth factors or their receptors may be overexpressed at variable levels and the contribution of these defects in human pituitaries tumorigenesis remains to be established.
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The activity of 11β-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas
Valentina Morelli,Elisa Polledri,R. Mercadante,Volha V. Zhukouskaya,Serena Palmieri,Paolo Beck-Peccoz,Anna Spada,Silvia Fustinoni,Iacopo Chiodini +8 more
TL;DR: In adrenal incidentaloma (AI) patients, the UFF increase is not associated with a UFE increase, and the HSD11B2 activity is inversely associated with UFF levels in n-UFF patients but not in h-UFF Patients, and it is notassociated with the SH complications.
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Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior.
Giovanna Mantovani,Giovanna Mantovani,Elena Giardino,Donatella Treppiedi,Rosa Catalano,Rosa Catalano,Federica Mangili,Anna Spada,Maura Arosio,Maura Arosio,Erika Peverelli +10 more
TL;DR: This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
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Mosaicism for GNAS methylation defects associated with pseudohypoparathyroidism type 1B arose in early post-zygotic phases
Francesca Elli,Paolo Bordogna,Maura Arosio,Maura Arosio,Anna Spada,Anna Spada,Giovanna Mantovani,Giovanna Mantovani +7 more
TL;DR: No correlation between methylation ratios, representing the proportion of epimutated cells, and the clinical presentation was found, further confirming the hypothesis of a threshold effect of the GNAS loss of imprinting leading to an “all-or-none” phenotype.
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Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment.
Eleonora Vitali,Ilena Boemi,Giulia Tarantola,Sara Piccini,Alessandro Zerbi,Giulia Veronesi,Roberto Baldelli,Gherardo Mazziotti,Valeria Smiroldo,Elisabetta Lavezzi,Anna Spada,Giovanna Mantovani,Andrea Lania +12 more
TL;DR: The combinatorial treatment of metformin and everolimus in combination is more effective than monotherapy in inhibiting colony formation, cell viability, NET spheroids growth rate and mTOR phosphorylation in both NET cell lines.